Radulović Niko S, Đorđević Zlatković Miljana R, Stojanović Nikola M, Nešić Milan S, Zlatković Dragan B, Potić Floranović Milena S, Tričković Vukić Dragana S, Randjelovic Pavle J
Department of Chemistry, Faculty of Sciences and Mathematics, University of Niš, 18000 Niš, Serbia.
Department of Physiology, Faculty of Medicine, University of Niš, 18000 Niš, Serbia.
Int J Mol Sci. 2024 Apr 19;25(8):4496. doi: 10.3390/ijms25084496.
Marrubiin is a diterpene with a long history of a wide range of biological activities. In this study, the anti-inflammatory effects of marrubiin were investigated using several in vitro and in vivo assays. Marrubiin inhibited carrageenan-induced peritoneal inflammation by preventing inflammatory cell infiltration and peritoneal mast cell degranulation. The anti-inflammatory activity was further demonstrated by monitoring a set of biochemical parameters, showing that the peritoneal fluid of animals treated with marrubiin had lower levels of proteins and lower myeloperoxidase activity compared with the fluid of animals that were not treated. Marrubiin exerted the most pronounced cytotoxic activity towards peripheral mononuclear cells, being the main contributors to peritoneal inflammation. Additionally, a moderate lipoxygenase inhibition activity of marrubiin was observed.
夏至草素是一种具有广泛生物活性悠久历史的二萜类化合物。在本研究中，使用多种体外和体内试验研究了夏至草素的抗炎作用。夏至草素通过防止炎症细胞浸润和腹膜肥大细胞脱颗粒来抑制角叉菜胶诱导的腹膜炎症。通过监测一组生化参数进一步证明了其抗炎活性，结果表明，与未治疗动物的腹腔液相比，用夏至草素治疗的动物腹腔液中的蛋白质水平较低，髓过氧化物酶活性也较低。夏至草素对作为腹膜炎症主要促成因素的外周单核细胞具有最显著的细胞毒性活性。此外，还观察到夏至草素具有适度的脂氧合酶抑制活性。
