Radocchia Giulia, Brunetti Francesca, Marazzato Massimiliano, Totino Valentina, Neroni Bruna, Bonfiglio Giulia, Conte Antonietta Lucia, Pantanella Fabrizio, Ciolli Paola, Schippa Serena
Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.
Policlinico Luigi Di Liegro, 00148 Rome, Italy.
Microorganisms. 2024 Apr 17;12(4):808. doi: 10.3390/microorganisms12040808.
Several studies have shown fluctuations in the maternal microbiota at various body sites (gut, oral cavity, and vagina). The skin microbiota plays an important role in our health, but studies on the changes during pregnancy are limited. Quantitative and qualitative variations in the skin microbiota in pregnant woman could indeed play important roles in modifying the immune and inflammatory responses of the host. These alterations could induce inflammatory disorders affecting the individual's dermal properties, and could potentially predict infant skin disorder in the unborn. The present study aimed to characterize skin microbiota modifications during pregnancy. For this purpose, skin samples were collected from 52 pregnant women in the first, second, and third trimester of non-complicated pregnancies and from 17 age- and sex-matched healthy controls. The skin microbiota composition was assessed by next generation sequencing (NGS) of the V3-V4 region of the bacterial rRNA 16S. Our results indicate that from the first to the third trimester of pregnancy, changes occur in the composition of the skin microbiota, microbial interactions, and various metabolic pathways. These changes could play a role in creating more advantageous conditions for fetal growth.
多项研究表明，母体微生物群在各个身体部位（肠道、口腔和阴道）存在波动。皮肤微生物群对我们的健康起着重要作用，但关于孕期变化的研究有限。孕妇皮肤微生物群的定量和定性变化确实可能在改变宿主的免疫和炎症反应中发挥重要作用。这些改变可能引发影响个体皮肤特性的炎症性疾病，并有可能预测未出生婴儿的皮肤疾病。本研究旨在描述孕期皮肤微生物群的变化。为此，从52名处于非复杂妊娠第一、第二和第三孕期的孕妇以及17名年龄和性别匹配的健康对照者身上采集了皮肤样本。通过对细菌rRNA 16S的V3-V4区域进行下一代测序（NGS）来评估皮肤微生物群的组成。我们的结果表明，从妊娠第一阶段到第三阶段，皮肤微生物群的组成、微生物相互作用和各种代谢途径都会发生变化。这些变化可能在为胎儿生长创造更有利条件方面发挥作用。
