Kazlauskaite Jurga Andreja, Matulyte Inga, Marksa Mindaugas, Bernatoniene Jurga
Department of Drug Technology and Social Pharmacy, Lithuanian University of Health Sciences, LT-50161 Kaunas, Lithuania.
Institute of Pharmaceutical Technologies, Lithuanian University of Health Sciences, LT-50161 Kaunas, Lithuania.
Pharmaceutics. 2024 Apr 12;16(4):530. doi: 10.3390/pharmaceutics16040530.
Encapsulating antioxidant-rich plant extracts, such as those found in red clover, within microcapsules helps protect them from degradation, thus improving stability, shelf life, and effectiveness. This study aimed to develop a microencapsulation delivery system using chitosan and alginate for microcapsules that dissolve in both the stomach and intestines, with the use of natural and synthetic emulsifiers. The microcapsules were formed using the extrusion method and employing alginate or chitosan as shell-forming material. In this study, all selected emulsifiers formed Pickering (β-CD) and traditional (white mustard extract, polysorbate 80) stable emulsions. Alginate-based emulsions resulted in microemulsions, while chitosan-based emulsions formed macroemulsions, distinguishable by oil droplet size. Although chitosan formulations with higher red clover extract (C1) concentrations showed potential, they exhibited slightly reduced firmness compared to other formulations (C2). Additionally, both alginate and chitosan formulations containing β-CD released bioactive compounds more effectively. The combined use of alginate and chitosan microcapsules in a single pill offers an innovative way to ensure dual solubility in both stomach and intestinal environments, increasing versatility for biomedical and pharmaceutical applications.
将富含抗氧化剂的植物提取物（如红三叶草中的提取物）包裹在微胶囊中，有助于保护它们不被降解，从而提高稳定性、保质期和有效性。本研究旨在开发一种使用壳聚糖和藻酸盐的微胶囊递送系统，用于在胃和肠道中均能溶解的微胶囊，并使用天然和合成乳化剂。微胶囊采用挤压法制备，以藻酸盐或壳聚糖作为成壳材料。在本研究中，所有选定的乳化剂均形成了皮克林（β-环糊精）和传统（白芥子提取物、聚山梨酯80）稳定乳液。基于藻酸盐的乳液形成微乳液，而基于壳聚糖的乳液形成宏观乳液，可通过油滴大小区分。尽管红三叶草提取物（C1）浓度较高的壳聚糖制剂显示出潜力，但与其他制剂（C2）相比，其硬度略有降低。此外，含有β-环糊精的藻酸盐和壳聚糖制剂均能更有效地释放生物活性化合物。在单一药丸中联合使用藻酸盐和壳聚糖微胶囊提供了一种创新方法，可确保在胃和肠道环境中均具有双重溶解性，增加了生物医学和制药应用的多功能性。
