Ghavipanjeh Gholamreza, Taeb Shahram, Farzin Mohammad Amin, Farhood Bagher, Najafi Masoud, Ardjmand Abolfazl
Institute for Basic Sciences, Physiology Research Center, Kashan University of Medical Sciences, Kashan, Iran.
Department of Radiology, School of Paramedical Sciences, Guilan University of Medical Sciences, Rasht, Iran.
Curr Drug Res Rev. 2025;17(2):322-327. doi: 10.2174/0125899775291111240409053824.
The aim of this study is to evaluate radioprotective effects of Cerebrolysin (CBL) in rats' brain tissues after local irradiation.
CBL has demonstrated antioxidant, anti-inflammatory, and tissue repair properties. In this study, the radioprotective effects of CBL in the brain tissues of rats after Irradiation (IR) (50 mg/ kg) were evaluated.
The levels of different oxidative stress markers, including malondialdehyde (MDA), nitric oxide (NO), glutathione peroxidase (GPx), catalase (CAT), and superoxide dismutase (SOD) were examined after treatment with radiation and CBL.
First, 20 male adult Wistar rats weighing 180-200 g were used. The animals were exposed to a single fraction of 15Gy using a linear accelerator unit at a dose rate of 200 cGy/mine. In this study, to check the amount of oxidative stress following the IR, the level of four markers MDA, NO, GPx, CAT, and SOD were examined and measured using the spectrophotometric method and purchased kits.
The results showed that compared to the IR group, the administration of CBL increases the levels of GPX and SOD significantly (p < 0.05).
Our finding suggests that CBL has radioprotective effects on the brain by enhancing antioxidant defense mechanisms.
本研究旨在评估脑蛋白水解物（CBL）对大鼠局部照射后脑组织的辐射防护作用。
CBL已显示出抗氧化、抗炎和组织修复特性。在本研究中，评估了CBL对照射（IR）（50毫克/千克）后大鼠脑组织的辐射防护作用。
在用辐射和CBL处理后，检测包括丙二醛（MDA）、一氧化氮（NO）、谷胱甘肽过氧化物酶（GPx）、过氧化氢酶（CAT）和超氧化物歧化酶（SOD）在内的不同氧化应激标志物的水平。
首先，使用20只体重180 - 200克的成年雄性Wistar大鼠。动物使用直线加速器以200厘戈瑞/分钟的剂量率接受单次15戈瑞的照射。在本研究中，为检查IR后的氧化应激量，使用分光光度法和购买的试剂盒检测并测量了四种标志物MDA、NO、GPx、CAT和SOD的水平。
结果表明，与IR组相比，给予CBL显著提高了GPX和SOD的水平（p < 0.05）。
我们的研究结果表明，CBL通过增强抗氧化防御机制对大脑具有辐射防护作用。
