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用于高级儿科脑肿瘤的患者来源的原位异种移植模型。

Patient-Derived Orthotopic Xenograft Models for High-Grade Pediatric Brain Cancers.

机构信息

Brain Tumor Research Program, Telethon Kids Cancer Centre, Telethon Kids Institute, Perth, WA, Australia.

Centre for Child Health Research, University of Western Australia, Perth, WA, Australia.

出版信息

Methods Mol Biol. 2024;2806:41-53. doi: 10.1007/978-1-0716-3858-3_5.

DOI:10.1007/978-1-0716-3858-3_5
PMID:38676795
Abstract

Patient-derived orthotopic xenograft (PDOX) mouse models are considered the gold standard for evidence-based preclinical research in pediatric neuro-oncology. This protocol describes the generation of PDOX models by intracranial implantation of human pediatric brain cancer cells into immune-deficient mice, and their continued propagation to establish cohorts of animals for preclinical research.

摘要

患者来源的原位异种移植（PDOX）小鼠模型被认为是小儿神经肿瘤学基于证据的临床前研究的金标准。本方案通过将人小儿脑癌细胞颅内植入免疫缺陷小鼠来生成 PDOX 模型，并继续传代以建立用于临床前研究的动物队列。

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本文引用的文献

1
loss of tumorigenicity in a patient-derived orthotopic xenograft mouse model of ependymoma.在室管膜瘤患者来源的原位异种移植小鼠模型中致瘤性的丧失
Front Oncol. 2023 Mar 3;13:1123492. doi: 10.3389/fonc.2023.1123492. eCollection 2023.
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Patient-derived models recapitulate heterogeneity of molecular signatures and drug response in pediatric high-grade glioma.患者来源模型再现了小儿高级别胶质瘤分子特征和药物反应的异质性。
Nat Commun. 2021 Jul 2;12(1):4089. doi: 10.1038/s41467-021-24168-8.
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and Pediatric Brain Tumor Models: An Overview.以及儿科脑肿瘤模型：概述
Front Oncol. 2021 Apr 1;11:620831. doi: 10.3389/fonc.2021.620831. eCollection 2021.
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A Novel Orthotopic Patient-Derived Xenograft Model of Radiation-Induced Glioma Following Medulloblastoma.一种新型的髓母细胞瘤后放射性胶质瘤原位患者来源异种移植模型。
Cancers (Basel). 2020 Oct 12;12(10):2937. doi: 10.3390/cancers12102937.
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Harmonization of postmortem donations for pediatric brain tumors and molecular characterization of diffuse midline gliomas.协调小儿脑肿瘤的死后捐献和弥漫性中线胶质瘤的分子特征。
Sci Rep. 2020 Jul 2;10(1):10954. doi: 10.1038/s41598-020-67764-2.
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Patient-derived orthotopic xenografts of pediatric brain tumors: a St. Jude resource.儿童脑肿瘤患者来源的原位异种移植瘤：圣裘德资源。
Acta Neuropathol. 2020 Aug;140(2):209-225. doi: 10.1007/s00401-020-02171-5. Epub 2020 Jun 10.
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Fibroblasts in the Tumor Microenvironment.肿瘤微环境中的成纤维细胞。
Adv Exp Med Biol. 2020;1234:15-29. doi: 10.1007/978-3-030-37184-5_2.
8
Genomic Profiling of Childhood Tumor Patient-Derived Xenograft Models to Enable Rational Clinical Trial Design.对儿童肿瘤患者衍生异种移植模型进行基因组分析，以实现合理的临床试验设计。
Cell Rep. 2019 Nov 5;29(6):1675-1689.e9. doi: 10.1016/j.celrep.2019.09.071.
9
A biobank of patient-derived pediatric brain tumor models.患者来源的小儿脑肿瘤模型生物银行。
Nat Med. 2018 Nov;24(11):1752-1761. doi: 10.1038/s41591-018-0207-3. Epub 2018 Oct 22.
10
Preclinical Models of Pediatric Brain Tumors-Forging Ahead.小儿脑肿瘤的临床前模型——向前迈进
Bioengineering (Basel). 2018 Oct 2;5(4):81. doi: 10.3390/bioengineering5040081.