Monsour P A, Kruger B J, Smid J R
J Dent Res. 1985 Nov;64(11):1281-5. doi: 10.1177/00220345850640110501.
This study assessed the effect of a single intravenous dose of sodium fluoride (20 mg/kg body wt.) on plasma ionic fluoride and on some other plasma electrolytes and metabolites in rats, rabbits, and cockerels. At any given time following sodium fluoride administration, the plasma ionic fluoride was highest in rabbits and lowest in cockerels. The rate of removal of fluoride from plasma was slower in rabbits as compared with that in the other two species. Plasma sodium, chloride, total protein, albumin, total globulins, and osmolality were not significantly altered by sodium fluoride in any of these three species. However, plasma phosphate (inorganic), urea, creatinine, and glucose were elevated, and plasma calcium was reduced in the rats and the rabbits, but none was significantly altered in the cockerels. The analyses indicated that species variability does exist in fluoride toxicity.
本研究评估了单次静脉注射氟化钠（20毫克/千克体重）对大鼠、家兔和公鸡血浆离子氟以及其他一些血浆电解质和代谢物的影响。在给予氟化钠后的任何特定时间，家兔血浆离子氟最高，公鸡最低。与其他两个物种相比，家兔血浆中氟的清除速率较慢。在这三个物种中，氟化钠均未显著改变血浆钠、氯、总蛋白、白蛋白、总球蛋白和渗透压。然而，大鼠和家兔的血浆无机磷酸盐、尿素、肌酐和葡萄糖升高，血浆钙降低，但公鸡均无显著变化。分析表明，氟毒性确实存在物种差异。
