Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, DK-2800 Kongens Lyngby, Denmark.
Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, DK-2800 Kongens Lyngby, Denmark.
Trends Biotechnol. 2024 Oct;42(10):1258-1272. doi: 10.1016/j.tibtech.2024.04.003. Epub 2024 Apr 26.
Detailed molecular understanding of the human organism is essential to develop effective therapies. Saccharomyces cerevisiae has been used extensively for acquiring insights into important aspects of human health, such as studying genetics and cell-cell communication, elucidating protein-protein interaction (PPI) networks, and investigating human G protein-coupled receptor (hGPCR) signaling. We highlight recent advances and opportunities of yeast-based technologies for cost-efficient chemical library screening on hGPCRs, accelerated deciphering of PPI networks with mating-based screening and selection, and accurate cell-cell communication with human immune cells. Overall, yeast-based technologies constitute an important platform to support basic understanding and innovative applications towards improving human health.
深入了解人类机体的分子机制对于开发有效的治疗方法至关重要。酿酒酵母被广泛用于深入了解人类健康的重要方面，例如研究遗传学和细胞间通讯、阐明蛋白质-蛋白质相互作用 (PPI) 网络以及研究人类 G 蛋白偶联受体 (hGPCR) 信号转导。我们强调了基于酵母的技术在 hGPCR 化学文库筛选方面的最新进展和机会，基于交配的筛选和选择加速 PPI 网络的破译，以及与人免疫细胞进行精确的细胞间通讯。总的来说，基于酵母的技术是支持深入了解和创新应用以改善人类健康的重要平台。
