State Key Laboratory of Food Science and Resources, Nanchang University, Nanchang 330047, China.
Aga Khan University, 3rd Parklands, Nairobi, Kenya.
Microbiol Res. 2024 Jul;284:127733. doi: 10.1016/j.micres.2024.127733. Epub 2024 Apr 25.
Bacterial extracellular vesicles (bEVs) represent spherical particles with diameters ranging from 20 to 400 nm filled with multiple parental bacteria-derived components, including proteins, nucleic acids, lipids, and other biomolecules. The production of bEVs facilitates bacteria interacting with their environment and exerting biological functions. It is increasingly evident that the bEVs play integral roles in both bacterial and host physiology, contributing to environmental adaptations to functioning as health promoters for their hosts. This review highlights the current state of knowledge on the composition, biogenesis, and diversity of bEVs and the mechanisms by which different bEVs elicit effects on bacterial physiology and host health. We posit that an in-depth exploration of the mechanistic aspects of bEVs activity is essential to elucidate their health-promoting effects on the host and may facilitate the translation of bEVs into applications as novel natural biological nanomaterials.
细菌细胞外囊泡（bEVs）是一种直径在 20 至 400nm 之间的球形颗粒，内部填充了多种源自母菌的成分，包括蛋白质、核酸、脂类和其他生物分子。bEVs 的产生有助于细菌与环境相互作用并发挥生物学功能。越来越多的证据表明，bEVs 在细菌和宿主生理中都发挥着重要作用，有助于细菌适应环境并促进宿主健康。本综述强调了目前对 bEVs 的组成、生物发生和多样性以及不同 bEVs 对细菌生理和宿主健康产生影响的机制的了解。我们认为，深入探索 bEVs 活性的机制方面对于阐明它们对宿主的促进健康作用至关重要，并可能促进将 bEVs 转化为新型天然生物纳米材料的应用。
