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IgG4 相关自身免疫性胰腺炎的最新进展。

Recent advances in IgG4-related autoimmune pancreatitis.

机构信息

Department of Gastrointestinal Surgery, Xijing Hospital, Air Force Medical University, Xi'an, China.

Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK.

出版信息

Pathol Res Pract. 2024 May;257:155331. doi: 10.1016/j.prp.2024.155331. Epub 2024 Apr 26.

Abstract

The incidence of IgG4-related autoimmune pancreatitis (IgG4-AIP) is high in Asia and other countries, and unnecessary treatment is often undertaken due to both missed diagnosis and misdiagnosis in clinical practice. Although IgG4-AIP has attracted increasing attention, the details of IgG4-AIP pathogenesis and systemic immune response, including its relationship to tumor pathogenesis, are still unclear. In recent years, research on serum immunological detection, pathological features, clinical manifestations, diagnosis and treatment measures for IgG4-AIP has gradually increased. It is of great importance to summarize and discuss the latest progress regarding IgG4-AIP disease.

摘要

IgG4 相关自身免疫性胰腺炎(IgG4-AIP)在亚洲和其他国家的发病率较高,由于临床实践中漏诊和误诊,常导致不必要的治疗。虽然 IgG4-AIP 已引起越来越多的关注,但 IgG4-AIP 发病机制和全身免疫反应的细节,包括其与肿瘤发病机制的关系,仍不清楚。近年来,对 IgG4-AIP 的血清免疫学检测、病理特征、临床表现、诊断和治疗措施的研究逐渐增多。总结和讨论 IgG4-AIP 疾病的最新进展具有重要意义。

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