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鲍温病伴阴茎浸润性鳞状细胞癌:病例报告及文献复习

Bowen's disease revealing a penile invasive squamous cell carcinoma: Case report and review of literature.

作者信息

El Aboudi Adam, Lakssir Jihad, Boualaoui Imad, Ibrahimi Ahmed, El-Sayegh Hachem, Nouini Yassine

机构信息

Department of Urology A, Ibn Sina Hospital, University of Rabat, Morocco.

出版信息

Int J Surg Case Rep. 2024 Jun;119:109662. doi: 10.1016/j.ijscr.2024.109662. Epub 2024 Apr 21.

Abstract

INTRODUCTION

Bowen's disease (BD) represents an in situ squamous cell carcinoma that can progress to an invasive one without treatment. Various options for Bowen's disease have been delineated, each with its set of advantages and disadvantages.

CASE PRESENTATION

We report the case of a 60-year-old patient with a history of chronic smoking and a background of multiple partners and recurrent urethritis. The patient presented with a maculopapular lesion on the lateral aspect of the penis, evolving for 5 years. A biopsy confirmed the diagnosis of Bowen's disease. The patient underwent an excision of the lesion which the histology showed an infiltrating basosquamous cell carcinoma.

DISCUSSION

The diagnosis of Bowen's disease requires a biopsy and is based on histological examination. Only surgical treatment allows for the identification, through histological analysis of the excised specimen, of any potential invasive area that may not have been identified in the biopsy. Nonsurgical therapies are also an option with high recurrence rates.

CONCLUSION

Bowen's disease management requires a personalized approach, considering factors like lesion characteristics, patient-related variables and treatment efficacy. An adapted follow-up is recommended due to the recurrence risk associated with various treatments.

摘要

引言

鲍温病(BD)是一种原位鳞状细胞癌,若不治疗可进展为浸润性癌。针对鲍温病已确定了多种治疗选择,每种都有其优缺点。

病例报告

我们报告一例60岁患者,有长期吸烟史,有多个性伴侣且反复患尿道炎。患者阴茎外侧出现斑丘疹病变,病程5年。活检确诊为鲍温病。患者接受了病变切除,组织学检查显示为浸润性基底鳞状细胞癌。

讨论

鲍温病的诊断需要活检,并基于组织学检查。只有手术治疗能够通过对切除标本的组织学分析,识别活检中可能未发现的任何潜在浸润区域。非手术治疗也是一种选择,但复发率较高。

结论

鲍温病的治疗需要个性化方法,要考虑病变特征、患者相关变量和治疗效果等因素。由于各种治疗都存在复发风险,建议进行适当的随访。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f31/11063890/bf79a26a07cb/gr1.jpg

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