van Putten L M
Prog Clin Biol Res. 1985;201:15-21.
In three mouse tumor models the effect of timing of adjuvant chemotherapy with a single dose of cyclophosphamide was studied. In one tumor, preoperative adjuvant therapy was better than postoperative therapy. In a second tumor, the reverse was the case, and in the third model there was no difference resulting from variation in the timing of cytostatic drug therapy. Obviously, the concept that a standard drug dose always gives a constant relative cell kill is not always a valid simplification of dose-effect relationships in chemotherapy.
在三种小鼠肿瘤模型中，研究了单剂量环磷酰胺辅助化疗的时间安排的效果。在一种肿瘤中，术前辅助治疗优于术后治疗。在第二种肿瘤中，情况则相反，而在第三种模型中，细胞抑制药物治疗时间的变化没有产生差异。显然，标准药物剂量总能产生恒定相对细胞杀伤率这一概念，并不总是对化疗中剂量-效应关系的有效简化。
