Department of Neurology, Jinqiu Hospital of Liaoning Province, Shenyang 110016, China.
Key Lab of Environmental Pollution and Microecology of Liaoning Province, Shenyang Medical College, Shenyang 110034, China.
Exp Gerontol. 2024 Jun 15;191:112444. doi: 10.1016/j.exger.2024.112444. Epub 2024 Apr 29.
The objective of the study was to systematically investigate the association between gut microbiota (GM) abundance and Parkinson's disease (PD).
PubMed, Medline, Cochrane Library and other literature datebase platforms were searched for eligible studies in the English-language from conception to March 1, 2024. Studies evaluating the association between GM and PD were included. The results of the included studies were analyzed using a random effects model with calculation of the mean difference (MD) with the 95 % confidence interval to quantify the incidence of differences in abundance of various bacterial families in PD patients. Continuous models were used to analyze the extracted data.
A total of 14 studies with 1045 PD cases and 821 healthy controls were included for data extraction and meta-analysis. All the included studies exhibited reasonable quality. The included studies reported the data on the ratios of 10 families of GM. Of these 10 microbiota families, Bifidobacteriaceae, Ruminococcaceae, Rikenellaceae, Lactobacillaceae, Verrucomicrobiaceae and Christensenellaceae were found to have increased ratios according to the pooled ratios, while Prevotellaceae, Lachnospiraceae, Erysipelotrichaceae and Faecalibacterium were decreased in PD cases.
Patients in the PD cohort exhibited distinctive microbiota compositions compared to healthy individuals, with unique differential patterns in gut microbiome abundance at the phylum, family, and genus levels that may be associated wtih PD pathogenesis.
本研究旨在系统研究肠道微生物群（GM）丰度与帕金森病（PD）之间的关联。
检索 PubMed、Medline、Cochrane Library 及其他文献数据库平台，检索从概念提出到 2024 年 3 月 1 日的英文文献，纳入评估 GM 与 PD 之间关联的研究。采用随机效应模型对纳入研究的结果进行分析，计算各种细菌家族丰度差异的均数差（MD）及其 95%置信区间，以量化 PD 患者中各种细菌家族丰度差异的发生率。采用连续模型分析提取的数据。
共纳入 14 项研究，包括 1045 例 PD 病例和 821 例健康对照者，用于提取和荟萃分析数据。所有纳入的研究均显示出合理的质量。纳入的研究报告了 GM 的 10 个家族的比值数据。在这 10 个微生物家族中，双歧杆菌科、瘤胃球菌科、真杆菌科、乳杆菌科、疣微菌科和克里斯滕森菌科的比例根据汇总比值显示出增加，而拟杆菌科、普雷沃氏菌科、肠杆菌科和粪杆菌科在 PD 病例中减少。
与健康个体相比，PD 队列患者表现出独特的微生物群落组成，在门、科和属水平的肠道微生物组丰度存在独特的差异模式，这可能与 PD 的发病机制有关。
