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GCGR: novel potential therapeutic target for chronic kidney disease.

作者信息

Hu Yan, Huang Hao, Xiang Rong

机构信息

Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University, Chengdu, 610041, China.

Department of Nephrology, Xiangya Hospital Central South University, Changsha, 410008, China.

出版信息

Sci China Life Sci. 2024 Jul;67(7):1542-1544. doi: 10.1007/s11427-024-2576-x. Epub 2024 Apr 26.

DOI:10.1007/s11427-024-2576-x
PMID:38679668
Abstract
摘要

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GCGR: novel potential therapeutic target for chronic kidney disease.胰高血糖素受体：慢性肾脏病新的潜在治疗靶点
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本文引用的文献

1
Downregulation of the kidney glucagon receptor, essential for renal function and systemic homeostasis, contributes to chronic kidney disease.肾脏胰高血糖素受体下调，对肾功能和全身内稳态至关重要，导致慢性肾脏病。
Cell Metab. 2024 Mar 5;36(3):575-597.e7. doi: 10.1016/j.cmet.2023.12.024. Epub 2024 Jan 17.
2
Energy Metabolism Dysregulation in Chronic Kidney Disease.慢性肾脏病中的能量代谢失调。
Kidney360. 2023 Aug 1;4(8):1080-1094. doi: 10.34067/KID.0000000000000153. Epub 2023 May 24.
3
Evaluation of commercially available glucagon receptor antibodies and glucagon receptor expression.
评估市售的胰高血糖素受体抗体和胰高血糖素受体表达。
Commun Biol. 2022 Nov 22;5(1):1278. doi: 10.1038/s42003-022-04242-7.
4
Vps37a regulates hepatic glucose production by controlling glucagon receptor localization to endosomes.Vps37a 通过控制胰高血糖素受体向内体的定位来调节肝脏的葡萄糖产生。
Cell Metab. 2022 Nov 1;34(11):1824-1842.e9. doi: 10.1016/j.cmet.2022.09.022. Epub 2022 Oct 14.
5
Evidence for Glucagon Secretion and Function Within the Human Gut.人体肠道内胰高血糖素分泌及功能的证据。
Endocrinology. 2021 Apr 1;162(4). doi: 10.1210/endocr/bqab022.
6
Resolution of NASH and hepatic fibrosis by the GLP-1R/GcgR dual-agonist Cotadutide via modulating mitochondrial function and lipogenesis.通过调节线粒体功能和脂生成，GLP-1R/GcgR 双重激动剂 Cotadutide 治疗 NASH 和肝纤维化。
Nat Metab. 2020 May;2(5):413-431. doi: 10.1038/s42255-020-0209-6. Epub 2020 May 21.
7
Comparison of Kidney Transcriptomic Profiles of Early and Advanced Diabetic Nephropathy Reveals Potential New Mechanisms for Disease Progression.早期和晚期糖尿病肾病的肾脏转录组谱比较揭示了疾病进展的潜在新机制。
Diabetes. 2019 Dec;68(12):2301-2314. doi: 10.2337/db19-0204. Epub 2019 Oct 2.
8
Metabolic pathways and immunometabolism in rare kidney diseases.罕见肾脏疾病中的代谢途径和免疫代谢
Ann Rheum Dis. 2018 Aug;77(8):1226-1233. doi: 10.1136/annrheumdis-2017-212935. Epub 2018 May 3.
9
Glucagon contributes to liver zonation.胰高血糖素有助于肝脏分区。
Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):E4111-E4119. doi: 10.1073/pnas.1721403115. Epub 2018 Mar 19.
10
Meta-analysis of polycystic kidney disease expression profiles defines strong involvement of injury repair processes.多囊肾病表达谱的荟萃分析定义了损伤修复过程的强烈参与。
Am J Physiol Renal Physiol. 2017 Apr 1;312(4):F806-F817. doi: 10.1152/ajprenal.00653.2016. Epub 2017 Feb 1.