Silva-Correa Carmen R, Torre Víctor E Villarreal-La, Lozano-Ciudad Gladys E, Gómez-Arce Ricardo M, Castañeda-Carranza Julio A, Dionicio-Rosado Deivy Y, Cotrina-León María E, Sagástegui-Guarniz William A, Gamarra-Sánchez César D, Cruzado-Razco José L
Departamento de Farmacología, Facultad de Farmacia y Bioquímica, Universidad Nacional de Trujillo, Perú.
Departamento de Estadística, Facultad de Ciencias Físicas y Matemáticas, Universidad Nacional de Trujillo, Perú.
Vet World. 2024 Mar;17(3):700-704. doi: 10.14202/vetworld.2024.700-704. Epub 2024 Mar 25.
Mill. () is an aromatic plant used in traditional medicine as an anti-inflammatory, anti-tussive, anti-rheumatic, and anti-diarrheal agent. This study aimed to evaluate the effect of Mill. on a var. -induced breast cancer model.
We collected from the province of Julcán, La Libertad Region, Per, and prepared an ethanolic extract using pulverized leaves macerated in 96° ethanol for 72 h with magnetic stirring. In the evaluation of anticancer activity, four experimental groups with 10 female rats each were formed: Group I (Control-7,12-dimethylbenz[a]anthracene [DMBA]), which received DMBA (single dose) and physiological saline solution for 4 months, and Groups II, III, and IV, which received DMBA (single dose) and 200, 400, and 600 mg/kg/day of the ethanolic extract of , respectively, for 4 months.
The DMBA control group presented histological characteristics of ductal carcinoma with necrotic and inflammatory areas, whereas the extract group showed a decrease in tumor volume and recovery of the ductal duct.
Ethanol extract of leaves decreases tumor development in rats with induced breast cancer, and this effect is dose-dependent.
Mill.（）是一种芳香植物，在传统医学中用作抗炎、止咳、抗风湿和止泻剂。本研究旨在评估Mill.对var.诱导的乳腺癌模型的影响。
我们从秘鲁自由地区胡尔坎省采集了，并使用在96°乙醇中研磨的叶子在磁力搅拌下浸泡72小时制备了乙醇提取物。在抗癌活性评估中，形成了四个实验组，每组10只雌性大鼠：第一组（对照-7,12-二甲基苯并[a]蒽[DMBA]），接受DMBA（单剂量）和生理盐水溶液4个月，第二组、第三组和第四组分别接受DMBA（单剂量）和200、400和600mg/kg/天的乙醇提取物4个月。
DMBA对照组呈现出伴有坏死和炎症区域的导管癌组织学特征，而提取物组显示肿瘤体积减小且导管恢复。
Mill.叶的乙醇提取物可减少诱导性乳腺癌大鼠的肿瘤发展，且这种作用具有剂量依赖性。
