Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
School of Pharmacy, Tianjin Medical University, Tianjin, China.
Cell Prolif. 2020 Oct;53(10):e12894. doi: 10.1111/cpr.12894. Epub 2020 Sep 3.
Cancer is the principal cause of death and a dominant public health problem which seriously threatening human life. Among various ways to treat cancer, traditional Chinese medicine (TCM) and natural products have outstanding anti-cancer effects with their unique advantages of high efficiency and minimal side effects. Cell senescence is a physiological process of cell growth stagnation triggered by stress, which is an important line of defence against tumour development. In recent years, active ingredients of TCM and natural products, as an interesting research hotspot, can induce cell senescence to suppress the occurrence and development of tumours, by inhibiting telomerase activity, triggering DNA damage, inducing SASP, and activating or inactivating oncogenes. In this paper, the recent research progress on the main compounds derived from TCM and natural products that play anti-cancer roles by inducing cell senescence is systematically reviewed, aiming to provide a reference for the clinical treatment of pro-senescent cancer.
癌症是主要的死亡原因，也是严重威胁人类生命的主要公共卫生问题。在治疗癌症的各种方法中，中药和天然产物具有突出的抗癌作用，具有高效和最小副作用的独特优势。细胞衰老（Cell senescence）是细胞生长停滞由压力触发的生理过程，是防止肿瘤发展的重要防线。近年来，中药和天然产物的活性成分作为一个有趣的研究热点，可以通过抑制端粒酶活性、触发 DNA 损伤、诱导 SASP、激活或失活致癌基因，诱导细胞衰老来抑制肿瘤的发生和发展。本文系统综述了中药和天然产物中主要化合物通过诱导细胞衰老发挥抗癌作用的最新研究进展，旨在为促衰老癌症的临床治疗提供参考。
