Enzymatic Debridement With NexobridReduces Surgery in Laser Doppler Imaging-Confirmed Deep Burns.

In contrast to tangential excision, enzymatic debridement with NexoBrid selectively removes non-viable tissue, allowing some deep dermal burn wounds to still heal conservatively. In this retrospective study, we investigated the reduction in surgery and associated scarring following enzymatic debridement in definitely deep burns as proven by laser Doppler imaging. One hundred two where there was no doubt at all about the surgical indication, were selected for analysis in 32 patients treated with NexoBrid. The total surface area of the 102 was 5,086.4cm. NexoBrid resulted in a substantial reduction in the need for autografts as 1,986.9cm (39%) healed with conservative treatment. This corresponded with a significant reduction in patients (56.3%) requiring surgery. treated surgically with split thickness skin grafts required significantly more time to heal compared to conservative treatment (37.8±17.5 vs. 27.0±10.5 days). A very limited rate of hypertrophic scarring (16.7%) was observed. This is the first paper demonstrating a proven and significant reduction in the extent of autografting as well as in the number of surgical procedures after selective enzymatic debridement in objectively laser Doppler imaging-defined and therefore proven deep burns. Even after extended conservative treatment with prolonged healing times following NexoBrid, hypertrophic scar formation was limited (5/54 regions of interest, 9.3%). Also in operated patients, the incidence of hypertrophic scarring following a strict regimen of aftercare was low (12/48 regions of interest, 25%).