Chemutai Sum Winnie, Ebada Sherif S, Kellner Harald, Stadler Marc
Department of Microbial Drugs, Helmholtz Centre for Infection Research GmbH (HZI), Inhoffenstraße 7, 38124 Braunschweig, Germany.
Institute of Microbiology, Technische Universität Braunschweig, Spielmannstraße 7, 38106 Braunschweig, Germany.
ACS Omega. 2024 Apr 11;9(16):18668-18673. doi: 10.1021/acsomega.4c02011. eCollection 2024 Apr 23.
Two unprecedented isomeric secondary metabolites named vibralactones Z () and Z (), in addition to eleven known compounds (-), were isolated from solid-state rice culture medium of (Bondarzewiaceae). Chemical structures of the isolated compounds were established via spectral analyses. The new lactone derivatives were weakly active against without any significant cytotoxicity, while the molecules containing an aldehyde functionality showed significant antimicrobial and cytotoxic effects. For instance, erinacine P () and (+)-isovelleral () and erinacine P () were cytotoxic against all tested cell lines at IC values in the ranges of 3.5-14.2 and 2.8-30.2 μM, respectively. In addition, they revealed moderate antimicrobial activity with the lowest minimum inhibitory concentration (MIC) values recorded against (8.3 μg/mL), , and at 16.6 μg/mL.
从齿菌科真菌的固态大米培养基中分离出两种前所未有的同分异构次生代谢产物，命名为振动内酯Z（）和Z（），以及十一种已知化合物（-）。通过光谱分析确定了分离出的化合物的化学结构。新的内酯衍生物对[具体对象未提及]活性较弱，且无明显细胞毒性，而含有醛官能团的分子则显示出显著的抗菌和细胞毒性作用。例如，齿孔酸P（）、（+）-异维勒醛（）和齿孔酸P（）对所有测试细胞系均具有细胞毒性，IC值分别在3.5 - 14.2和2.8 - 30.2 μM范围内。此外，它们还显示出中等抗菌活性，对[具体对象未提及]的最低抑菌浓度（MIC）值最低，为8.3 μg/mL，对[具体对象未提及]和[具体对象未提及]的MIC值为16.6 μg/mL。
