Sum Winnie Chemutai, Mitschke Nico, Schrey Hedda, Wittstein Kathrin, Kellner Harald, Stadler Marc, Matasyoh Josphat Clement
Department Microbial Drugs, Helmholtz Centre for Infection Research GmbH (HZI), Inhoffenstraße 7, 38124 Braunschweig, Germany.
Research Group for Marine Geochemistry (ICBM-MPI Bridging Group), Institute for Chemistry and Biology of the Marine Environment (ICBM), Carl von Ossietzky Universität Oldenburg, Carl-von-Ossietzky-Str. 9-11, 26129 Oldenburg, Germany.
Antibiotics (Basel). 2022 Aug 8;11(8):1072. doi: 10.3390/antibiotics11081072.
In our continued search for biologically active metabolites from cultures of rare Basidiomycota species, we found eight previously undescribed cyathane-xylosides from submerged cultures of , which were named dentifragilins A-H. In addition, the known cyathane derivatives striatal D and laxitextine A were isolated. All compounds were characterized by high-resolution electrospray ionization mass spectrometry (HR-ESIMS) as well as by 1D and 2D nuclear magnetic resonance (NMR) spectroscopy. Several of the compounds exhibited significant activities in standardized cell-based assays for the determination of antimicrobial and cytotoxic effects. The discovery of cyathanes in the genus has chemotaxonomic implications, as this class of diterpenoids has already been shown to be characteristic for mycelial cultures of the related genera and , which are classified as in the family Hericiaceae.
在我们持续从稀有担子菌物种培养物中寻找生物活性代谢物的过程中，我们从[物种名称未给出]的深层培养物中发现了8种先前未描述的紫杉烷-木糖苷，它们被命名为牙碎菌素A-H。此外，还分离出了已知的紫杉烷衍生物纹状体D和松皮菌素A。所有化合物均通过高分辨率电喷雾电离质谱（HR-ESIMS）以及一维和二维核磁共振（NMR）光谱进行了表征。在用于测定抗菌和细胞毒性作用的标准化细胞实验中，几种化合物表现出显著活性。在[属名未给出]属中发现紫杉烷具有化学分类学意义，因为这类二萜已被证明是相关属[两个属名未给出]菌丝体培养物的特征，这两个属在刺孢菌科中被归类为[具体分类未给出]。
