Maeda Kenichi, Hotta Daiki, Matsui Takuma, Iwai Satomi, Okanao Shozo
Kitasato University School of Veterinary Medicine, Towada, Japan.
J Adv Vet Anim Res. 2024 Mar 12;11(1):27-32. doi: 10.5455/javar.2024.k743. eCollection 2024 Mar.
To evaluate the effect of water temperature on intramuscular injected alfaxalone anesthesia in carp ().
Six healthy adult carp () were intramuscularly injected with alfaxalone (2.5, 5.0, or 7.5 mg/kg) at normal water temperature (25°C) and at low water temperature (2.5 mg/kg, 15°C). The respiratory rate, heart rate (HR), and anesthesia depth (AD) were evaluated every 5 min for 30 min after administration and every 1 h after 60 min after injection.
The respiratory and HRs did not change significantly upon alfaxalone injection, regardless of dose. However, a dose-dependent increase in AD scores was observed. Furthermore, 2.5 mg/kg alfaxalone injected in 15°C water showed an almost equal anesthetic effect to that of 5.0 mg/kg alfaxalone in 25°C water.
Alfaxalone is readily available, and its anesthetic effect in carp was enhanced by lowering water temperature, illustrating the possibility of intramuscular injection of alfaxalone in fish.
评估水温对鲤鱼肌肉注射阿法沙龙麻醉效果的影响。
选取6条健康成年鲤鱼，在正常水温（25°C）下肌肉注射阿法沙龙（2.5、5.0或7.5 mg/kg），并在低水温（15°C）下注射2.5 mg/kg阿法沙龙。给药后30分钟内每5分钟评估一次呼吸频率、心率（HR）和麻醉深度（AD），注射60分钟后每1小时评估一次。
无论剂量如何，注射阿法沙龙后呼吸频率和心率均无显著变化。然而，观察到麻醉深度评分呈剂量依赖性增加。此外，在15°C水中注射2.5 mg/kg阿法沙龙的麻醉效果与在25°C水中注射5.0 mg/kg阿法沙龙的麻醉效果几乎相同。
阿法沙龙易于获取，降低水温可增强其对鲤鱼的麻醉效果，这表明在鱼类中肌肉注射阿法沙龙具有可行性。
