Zhang Jing, Hou Yilin, Zhang Zhaozi, Shi Yihe, Wang Zhimin, Song Guangyao
Department of Internal Medicine, Graduate School of Hebei Medical University, Shijiazhuang, Hebei, People's Republic of China.
Department of Endocrinology, Hebei General Hospital, Shijiazhuang, Hebei, People's Republic of China.
Diabetes Metab Syndr Obes. 2024 Apr 23;17:1833-1843. doi: 10.2147/DMSO.S450738. eCollection 2024.
Peroxidation is one of the important causes of insulin resistance (IR), and vitamin E is a natural antioxidant, and there may be some correlation between serum vitamin E levels and insulin resistance.
The correlation between serum vitamin E and insulin resistance in type 2 diabetes mellitus (T2DM) population.
Two hundred and forty-two people (119 with T2DM) were included. One hundred and nineteen patients with T2DM were selected as the case group, and 123 people with non-T2DM were selected as the control group. People insulin resistance was detected by the homeostasis model assessment method (HOMA-IR) greater than 2.69 were included in the diabetic insulin resistance group, and those with HOMA-IR less than 2.69 were included in the diabetic non-insulin resistance group. Record the general body indicators, biochemical indicators, hepatic function indicators, vitamin E, and other indicators. Correlation analysis, logistic regression, trend analysis, and restricted cubic spline (RCS) were performed using SPSS 25.0 and R 4.1.1 software. Correlation analysis, logistic regression, trend analysis, restricted cubic spline (RCS) analysis were conducted on general body indicators, biochemical indicators, hepatic function indicators, vitamin E, and other indicators.
The logistic regression results showed that after adjusting for confounding factors, vitamin E was an independent influencing factor for insulin resistance in T2DM patients (P < 0.001). The trend analysis results show that with the decrease of serum vitamin E levels, the risk of insulin resistance in T2DM patients gradually increases. The RCS results showed that the risk of insulin resistance was significantly increased when the serum vitamin E level was lower than 10,575.23 ng/mL.
Serum vitamin E levels are lower in T2DM patients than in healthy populations; Vitamin E is an independent influencing factor for HOMA-IR in T2DM patients. The risk of insulin resistance gradually increases in T2DM patients as serum vitamin E levels decrease. Vitamin E is a risk factor for insulin resistance at serum vitamin E levels below 10,575.23 ng/mL. At higher serum vitamin E levels than 10,575.23 ng/mL, vitamin E is a protective factor for insulin resistance.
过氧化是胰岛素抵抗（IR）的重要原因之一，维生素E是一种天然抗氧化剂，血清维生素E水平与胰岛素抵抗之间可能存在一定关联。
探讨2型糖尿病（T2DM）人群血清维生素E与胰岛素抵抗的相关性。
纳入242人（其中119例T2DM患者）。选取119例T2DM患者作为病例组，123例非T2DM患者作为对照组。采用稳态模型评估法（HOMA-IR）检测人群胰岛素抵抗，HOMA-IR大于2.69者纳入糖尿病胰岛素抵抗组，HOMA-IR小于2.69者纳入糖尿病非胰岛素抵抗组。记录一般身体指标、生化指标、肝功能指标、维生素E等指标。使用SPSS 25.0和R 4.1.1软件进行相关性分析、逻辑回归、趋势分析和限制性立方样条（RCS）分析。对一般身体指标、生化指标、肝功能指标、维生素E等指标进行相关性分析、逻辑回归、趋势分析、限制性立方样条（RCS）分析。
逻辑回归结果显示，校正混杂因素后，维生素E是T2DM患者胰岛素抵抗的独立影响因素（P < 0.001）。趋势分析结果表明，随着血清维生素E水平的降低，T2DM患者胰岛素抵抗风险逐渐增加。RCS结果显示，血清维生素E水平低于10575.23 ng/mL时，胰岛素抵抗风险显著增加。
T2DM患者血清维生素E水平低于健康人群；维生素E是T
