女性镁摄入量、胰岛素抵抗与血管内皮功能标志物。
Magnesium intake, insulin resistance and markers of endothelial function among women.
机构信息
Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
出版信息
Public Health Nutr. 2021 Dec;24(17):5777-5785. doi: 10.1017/S1368980021001063. Epub 2021 Mar 15.
OBJECTIVE
We investigated the association of dietary Mg intake with insulin resistance and markers of endothelial function among Iranian women.
DESIGN
A cross-sectional study.
SETTING
Usual dietary intakes were assessed using a validated FFQ. Dietary Mg intake was calculated by summing up the amount of Mg in all foods. A fasting blood sample was taken to measure serum concentrations of glycemic indices (fasting plasma glucose and insulin) and endothelial function markers (E-selectin, soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1). Insulin resistance and sensitivity were estimated using the Homeostasis Model Assessment-Insulin Resistance (HOMA-IR), Homeostasis Model Assessment β-cell function (HOMA-β) and quantitative insulin sensitivity check index (QUICKI).
PARTICIPANTS
Iranian female nurses (n 345) selected by a multistage cluster random sampling method.
RESULTS
The Mg intake across energy-adjusted quartiles was 205 (se 7), 221·4 (se 8), 254·3 (se 7) and 355·2 (se 9) mg/d, respectively. After adjustments for potential confounders, QUICKI level was significantly different across quartiles of Mg intake (Q1: 0·34 (se 0·02), Q2: 0·36 (se 0·01), Q3: 0·40 (se 0·01), and Q4: 0·39 (se 0·02), P = 0·02); however, this association disappeared after considering markers of endothelial function, indicating that this relation might be mediated through endothelial dysfunction. After controlling for all potential confounders, Mg intake was inversely, but not significantly, associated with serum concentrations of sICAM (Q1: 239 (se 17), Q2: 214 (se 12), Q3: 196 (se 12), and Q4: 195 (se 17), P = 0·29). There was no other significant association between dietary Mg intake and other indicators of glucose homoeostasis or endothelial markers.
CONCLUSIONS
Higher dietary Mg intake was associated with better insulin sensitivity in Iranian females. This linkage was mediated through reduced endothelial dysfunction.
目的
我们旨在研究伊朗女性膳食镁摄入量与胰岛素抵抗和内皮功能标志物之间的关联。
设计
横断面研究。
地点
使用经过验证的食物频数问卷评估习惯性膳食摄入量。通过将所有食物中的镁含量相加来计算膳食镁摄入量。采集空腹血样以测量血糖指数（空腹血糖和胰岛素）和内皮功能标志物（E-选择素、可溶性细胞间黏附分子-1（sICAM-1）和可溶性血管细胞黏附分子-1）的血清浓度。使用稳态模型评估胰岛素抵抗（HOMA-IR）、稳态模型评估β细胞功能（HOMA-β）和定量胰岛素敏感性检查指数（QUICKI）来估计胰岛素抵抗和敏感性。
参与者
通过多阶段聚类随机抽样方法选择的伊朗女性护士（n 345）。
结果
经能量调整后的四分位区间的镁摄入量分别为 205（se 7）、221·4（se 8）、254·3（se 7）和 355·2（se 9）mg/d。在调整潜在混杂因素后，镁摄入量四分位区间的 QUICKI 水平存在显著差异（Q1：0·34（se 0·02），Q2：0·36（se 0·01），Q3：0·40（se 0·01），Q4：0·39（se 0·02），P = 0·02）；然而，考虑到内皮功能标志物后，这种关联消失了，表明这种关系可能通过内皮功能障碍介导。在控制所有潜在混杂因素后，镁摄入量与血清 sICAM 浓度呈负相关，但无统计学意义（Q1：239（se 17），Q2：214（se 12），Q3：196（se 12），Q4：195（se 17），P = 0·29）。膳食镁摄入量与其他血糖稳态指标或内皮标志物之间没有其他显著关联。
结论
较高的膳食镁摄入量与伊朗女性的胰岛素敏感性增强有关。这种关联是通过减少内皮功能障碍介导的。
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