Fabry A
Arch Toxicol Suppl. 1985;8:124-7. doi: 10.1007/978-3-642-69928-3_18.
The incidence of neoplasms is presented for 600 Syrian hamsters (Mesocricetus auratus) used as controls in the evaluation of carcinogenicity of various experimental viral vaccines administered as a single subcutaneous injection at birth. Approximately 30% of the animals had neoplasms with no appreciable sex difference in the overall tumor incidence. The most frequent tumor types were those of the adrenal cortex (13.5%), the lymphoreticular system (3%), and the endometrium (3%). Small intestinal adenocarcinomas occurred in 0.8% of the animals. In this laboratory, the incidence of intestinal tumors is greater and more variable than that in the mouse or the rat. Furthermore, several unusual morphologic and biologic features of this tumor type were identified. These findings raise questions about the suitability of the Syrian hamster in carcinogenic bioassays.
本文呈现了600只叙利亚仓鼠（金仓鼠）的肿瘤发生率，这些仓鼠在出生时经单次皮下注射接种各种实验性病毒疫苗，用于评估其致癌性，作为对照。约30%的动物患有肿瘤，总体肿瘤发生率无明显性别差异。最常见的肿瘤类型是肾上腺皮质肿瘤（13.5%）、淋巴网状系统肿瘤（3%）和子宫内膜肿瘤（3%）。小肠腺癌发生于0.8%的动物。在本实验室中，肠道肿瘤的发生率高于小鼠或大鼠，且更具变异性。此外，还发现了这种肿瘤类型的一些不寻常的形态学和生物学特征。这些发现引发了关于叙利亚仓鼠在致癌生物测定中适用性的疑问。
