Riess W
Arch Toxicol Suppl. 1985;8:189-95. doi: 10.1007/978-3-642-69928-3_28.
Toxicological risk assessment requires knowledge of the kinetics of the test compound and its metabolites in the respective animal species. The toxic effects are dependent on the maximum, minimum, integral and mean systemic exposure as well as its fluctuation index at steady state. If these variables are set appropriately, defined toxicological hypotheses can be tested: the assessment of the no-effect dose level, the evaluation of the toxicological significance of high peak versus attenuated systemic exposure and the toxicological rating of species-specific metabolic pathways.
毒理学风险评估需要了解受试化合物及其代谢产物在相应动物物种中的动力学。毒性效应取决于稳态时的最大、最小、积分和平均全身暴露量及其波动指数。如果适当地设定这些变量，就可以检验明确的毒理学假设：无效应剂量水平的评估、高峰值与减弱的全身暴露的毒理学意义评估以及物种特异性代谢途径的毒理学评级。
