Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA, USA.
Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, USA.
Biomater Sci. 2024 May 28;12(11):2841-2864. doi: 10.1039/d3bm01861j.
Polymer-based biomaterials have received a lot of attention due to their biomedical, agricultural, and industrial potential. Soluble protein-polymer bioconjugates, immobilized proteins, and encapsulated proteins have been shown to tune enzymatic activity, improved pharmacokinetic ability, increased chemical and thermal stability, stimuli responsiveness, and introduced protein recovery. Controlled polymerization techniques, increased protein-polymer attachment techniques, improved polymer surface grafting techniques, controlled polymersome self-assembly, and sophisticated characterization methods have been utilized for the development of well-defined polymer-based biomaterials. In this review we aim to provide a brief account of the field, compare these methods for engineering biomaterials, provide future directions for the field, and highlight impacts of these forms of bioconjugation.
基于聚合物的生物材料因其在生物医学、农业和工业方面的潜力而受到广泛关注。已证明可溶性蛋白-聚合物生物缀合物、固定化蛋白和包封蛋白可以调节酶活性、改善药代动力学能力、提高化学和热稳定性、响应刺激以及实现蛋白质回收。控制聚合技术、增加蛋白-聚合物连接技术、改进聚合物表面接枝技术、控制聚合物囊泡自组装和复杂的表征方法已被用于开发具有良好定义的基于聚合物的生物材料。在这篇综述中，我们旨在简要介绍该领域，比较这些用于工程生物材料的方法，为该领域提供未来的方向，并强调这些生物缀合形式的影响。
