Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, P.R. China.
Yunnan International Joint Laboratory of Vector Biology and Control and Yunnan Provincial Key Laboratory of Vector-Borne Diseases Control and Research of Yunnan Institute of Parasitic Diseases, Puer, P.R. China.
Vector Borne Zoonotic Dis. 2024 Oct;24(10):689-693. doi: 10.1089/vbz.2024.0007. Epub 2024 Apr 29.
is one of the most well known and largest virus families, including some animal and human pathogens, such as the Hendra, Nipah, and Rinderpest viruses, with a high potential for the emergence of human diseases. Based on recent phylogenetic analyses, two new genera ( and ) have been described. The newly recognized genus has rapidly increased in number and has grown to 15 species from 7 a few years ago. However, little is known about the diversity, host range, or evolution of . As a well-known host reservoir for many pathogens, rodents have always been the focus for characterizing their pathogenic potential. In this study, we isolated a Tailam virus strain (RN-JH-YN-2022-1) belonging to the genus from in Yunnan Province, China. The virus presented a near-complete genome (19,046 nucleotides). Similar to other members of the genus , the genome of RN-JH-YN-2022-1 contains eight basic genes (3'-N-P/V/C-M-F-SH-TM-G-L-5') with 88.88% sequence identity to Tailam virus (TL8K). Additionally, we discuss the pattern of genus diversity and the possible route of spread of the Tailam virus, which could provide new clues into the host range, virus diversity, and geographical distribution of the genus .
是最著名和最大的病毒家族之一，包括一些动物和人类病原体，如亨德拉、尼帕和牛瘟病毒，具有很高的人类疾病出现潜力。基于最近的系统发育分析，已经描述了两个新属（和）。新确认的属迅速增加，从几年前的 7 种增加到 15 种。然而，关于的多样性、宿主范围或进化知之甚少。作为许多病原体的知名宿主库，啮齿动物一直是表征其致病潜力的重点。在这项研究中，我们从云南省分离到一种属于的长尾病毒株（RN-JH-YN-2022-1）。该病毒呈现出近乎完整的基因组（19046 个核苷酸）。与属的其他成员相似，RN-JH-YN-2022-1 的基因组包含八个基本基因（3'-N-P/V/C-M-F-SH-TM-G-L-5'），与长尾病毒（TL8K）的序列同一性为 88.88%。此外，我们讨论了属多样性的模式和长尾病毒传播的可能途径，这可能为该属的宿主范围、病毒多样性和地理分布提供新的线索。
