从俄罗斯田鼠肾脏中分离出的一种新型副粘病毒——田鼠病毒（BaVV）的基因特征分析。

Genetic characterization of bank vole virus (BaVV), a new paramyxovirus isolated from kidneys of bank voles in Russia.

作者信息

Alkhovsky Sergey, Butenko Alexander, Eremyan Aykaz, Shchetinin Alexey

机构信息

D.I. Ivanovsky Institute of Virology, N.F. Gamaleya Federal Research Center for Epidemiology and Microbiology, Ministry of Healthcare of the Russian Federation, 18 Gamaleya str, Moscow, 123098, Russia.

出版信息

Arch Virol. 2018 Mar;163(3):755-759. doi: 10.1007/s00705-017-3639-z. Epub 2017 Nov 11.

DOI:10.1007/s00705-017-3639-z

PMID:29129019

Abstract

A genome of bank vole virus (BaVV), isolated from kidney tissues of bank voles (Myodes glareolus) in Russia in 1973, was sequenced. The genomic organization of BaVV (3'-N-P/V/C-M-F-G-L-5', 16,992 nt in length; GenBank accession number MF943130) is most similar to that of Mossman virus (MoV) and Nariva virus (NarPV), two ungrouped paramyxoviruses isolated from rodents in Australia and Trinidad, respectively. The proteins of BaVV have the highest level of sequence identity (ranging from 23-28% for G protein to 66-73% for M protein) to proteins of MoV and NarPV. The results of genetic and phylogenetic analysis suggest that BaVV represents a new species and, together with MoV and NarPV, belongs to a new, yet not established genus of the family Paramyxoviridae.

摘要

对1973年从俄罗斯棕背䶄（Myodes glareolus）肾脏组织中分离出的棕背䶄病毒（BaVV）的基因组进行了测序。BaVV的基因组结构（3'-N-P/V/C-M-F-G-L-5'，长度为16,992个核苷酸；GenBank登录号MF943130）与莫斯曼病毒（MoV）和纳里瓦病毒（NarPV）最为相似，这两种未分类的副粘病毒分别从澳大利亚和特立尼达的啮齿动物中分离得到。BaVV的蛋白质与MoV和NarPV的蛋白质具有最高水平的序列同一性（G蛋白为23%-28%，M蛋白为66%-73%）。遗传和系统发育分析结果表明，BaVV代表一个新物种，并且与MoV和NarPV一起，属于副粘病毒科一个新的、尚未确定的属。