Department of Dermatology, University of Michigan, Ann Arbor, Michigan, USA.
Carle Illinois College of Medicine, Urbana, Illinois, USA.
Pediatr Dermatol. 2024 Jul-Aug;41(4):660-666. doi: 10.1111/pde.15639. Epub 2024 Apr 29.
Acrochordons or skin tags are common benign skin growths. Several studies explored the relationship between obesity and metabolic syndrome in adults but remains unexplored in children.
This was a single-center retrospective cohort study of outpatient dermatology patients between 1 January 2000 to 1 January 2021. Children under 18 years old diagnosed with acrochordons using diagnostic codes International Classification of Diseases, 10th Revision (ICD-10) L91.8 and 9th Revision (ICD-9) 701.8 were included. We collected patient demographics, past medical history, laboratory values, vital signs, and physical exam. Body mass index (BMI) was calculated and stratified into categories based on the Center for Disease Control's BMI-for-Age Growth Charts. Metabolic syndrome was diagnosed when three of the five criteria were met. Data were propensity-matched and compared with NHANES (National Health and Nutrition Examination Survey), which offered a generalizable sample to the US population.
Fifty-five patients under 18 years old with a diagnosis of acrochordons were mostly Caucasian (76%) and female (64%). The mean BMI was 27.3, with 49.5% categorized as obese and 20% as overweight. The mean age of diagnosis was 10.1 years. Acrochordon predominantly appeared in the axilla. In our cohort, three patients (5.5%) met the criteria for metabolic syndrome. The prevalence of obesity (42% vs. 21%), type 2 diabetes mellitus (4.8% vs. 0.6%), hyperlipidemia (8.1% vs. 0%), and hypertension (1.6% vs. 0%) was greater in our cohort compared with NHANES.
Like the adult population, acrochordons may serve as marker for metabolic disease in the pediatric population.
皮赘又称皮肤软纤维瘤，是一种常见的良性皮肤赘生物。已有多项研究探讨了肥胖症与成人代谢综合征之间的关系，但儿童人群中的相关研究仍较少。
这是一项单中心回顾性队列研究，纳入了 2000 年 1 月 1 日至 2021 年 1 月 1 日期间在门诊皮肤科就诊的患者。符合以下条件的 18 岁以下儿童被诊断为皮赘：使用国际疾病分类第 10 版（ICD-10）L91.8 和第 9 版（ICD-9）701.8 诊断代码诊断为皮赘。我们收集了患者的人口统计学、既往病史、实验室检查值、生命体征和体格检查结果。计算体重指数（BMI）并根据疾病预防控制中心的 BMI 年龄生长图表进行分类。当满足以下五项标准中的三项时，诊断为代谢综合征。使用倾向评分匹配方法，将数据与美国国家健康和营养调查（NHANES）进行比较，该调查提供了一个具有代表性的美国人群样本。
55 例 18 岁以下的皮赘患者中，大多数为白种人（76%）和女性（64%）。平均 BMI 为 27.3，49.5%的患者被归类为肥胖，20%为超重。平均诊断年龄为 10.1 岁。皮赘主要出现在腋窝。在我们的队列中，有 3 名患者（5.5%）符合代谢综合征的标准。与 NHANES 相比，我们的队列中肥胖症（42% vs. 21%）、2 型糖尿病（4.8% vs. 0.6%）、血脂异常（8.1% vs. 0%）和高血压（1.6% vs. 0%）的患病率更高。
与成人人群一样，皮赘可能是儿童代谢疾病的标志物。
