Department of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Department of Gastroenterology, Liupanshui People's Hospital, Liupanshui City 553000, Guizhou Province, China.
Steroids. 2024 Jul;207:109426. doi: 10.1016/j.steroids.2024.109426. Epub 2024 Apr 27.
Multiple epidemiologic studies have revealed that gender is considered one of the important factors in the frequency and severity of certain infectious diseases, in which estrogens may play a vital role. There is growing evidence that estrogens as female sex hormone can modulate multiple biological functions outside of the reproductive system, such as in brain and cardiovascular system. However, it is largely unknown about the roles and mechanisms of estrogens/estrogen receptors in immune health and infection disease. Thence, by reading a lot of literature, we summarized the regulatory mechanisms of estrogens/estrogen receptors in immune cells and their roles in certain infectious diseases with gender differences. Therefore, estrogens may have therapeutic potentials to prevent and treat these infectious diseases, which needs further clinical investigation.
多项流行病学研究表明，性别被认为是某些传染病的频率和严重程度的重要因素之一，而雌激素可能在此过程中发挥着重要作用。越来越多的证据表明，作为女性性激素的雌激素可以调节生殖系统以外的多种生物学功能，如大脑和心血管系统。然而，关于雌激素/雌激素受体在免疫健康和传染病中的作用和机制在很大程度上尚不清楚。因此，通过大量文献阅读，我们总结了雌激素/雌激素受体在免疫细胞中的调节机制及其在具有性别差异的某些传染病中的作用。因此，雌激素可能具有预防和治疗这些传染病的治疗潜力，这需要进一步的临床研究。
