Wei Xiangrui, Hong Longyan, Liang Hao, Ren Ke, Man Wenqing, Zhao Yinghui, Guo Pengbo
Department of Health Inspection and Quarantine, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China.
Department of Clinical Laboratory Medicine, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Medicine and Health Key Laboratory of Laboratory Medicine, Jinan, Shandong, China.
Front Immunol. 2025 May 16;16:1556728. doi: 10.3389/fimmu.2025.1556728. eCollection 2025.
Gender differences exist in the susceptibility, incidence, progression, and prognosis of diseases caused by viral infections. These differences are influenced by various factors, including lifestyle and habits between males and females. Some reports have pointed out that estrogen plays an important immune-modulatory role in many viral infections. In certain viral infections, estrogen exhibits a protective and regulatory effect, while in others, it has a synergistic and promoting effect. The action of estrogen and its receptors affect the occurrence and prognosis of viral infections to some extent. This article reviews the correlation and the related mechanisms between estrogen and viral infections.
病毒感染所引起疾病的易感性、发病率、进展及预后存在性别差异。这些差异受多种因素影响，包括男性和女性的生活方式与习惯。一些报告指出，雌激素在许多病毒感染中发挥重要的免疫调节作用。在某些病毒感染中，雌激素表现出保护和调节作用，而在另一些感染中则具有协同和促进作用。雌激素及其受体的作用在一定程度上影响病毒感染的发生和预后。本文综述雌激素与病毒感染之间的相关性及相关机制。
