Xia Shijun, Zhu Yuwen, Wu Wenjiang, Li Yue, Yu Linchong
Shenzhen Hospital of Guangzhou University of Chinese Medicine, Shenzhen, China.
Front Oncol. 2024 Apr 15;14:1397197. doi: 10.3389/fonc.2024.1397197. eCollection 2024.
The effect of total intravenous anaesthesia (TIVA) and inhalation anaesthesia (IA) on the prognosis of patients with colorectal cancer after resection is controversial. This study aimed to explore the effects of different anaesthesia methods on the postoperative prognosis of colorectal cancer.
PubMed, Embase and Cochrane Library databases were searched for relevant literature from each database's inception until 18 November 2023. The literature topic was to compare the effects of TIVA and IA on the prognosis of patients undergoing colorectal cancer resection.
Six studies were selected for meta-analysis. The studies involved 111043 patients, with a trial size of 1001-88184 people. A statistically significant difference was observed in the overall survival (OS) between colorectal cancer patients administered TIVA and IA (hazard ratio [HR], 0.83; 95% confidence interval [CI], 0.70-0.99), but none in recurrence-free survival (RFS) (HR, 0.99; 95% CI, 0.90-1.08). In the subgroup analysis of OS, no statistically significant difference was observed between colorectal cancer patients administered TIVA and IA in Asia (HR, 0.77; 95% CI, 0.57-1.05), and not in Europe (HR, 0.99; 95% CI, 0.93-1.06). Regarding tumour location, no significant association was found between TIVA and IA in the colon, rectum and colorectum ((HR, 0.70; 95% CI, 0.38-1.28), (HR, 0.95; 95% CI, 0.83-1.08) and (HR, 0.99; 95% CI, 0.93-1.06), respectively).
OS differed significantly between patients administered TIVA and IA when undergoing colorectal cancer resection, but no difference was observed in RFS. The prognostic effects of TIVA and IA differed.
https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023453185, identifier CRD42023453185.
全静脉麻醉（TIVA）和吸入麻醉（IA）对结直肠癌患者切除术后预后的影响存在争议。本研究旨在探讨不同麻醉方法对结直肠癌患者术后预后的影响。
检索PubMed、Embase和Cochrane图书馆数据库，从各数据库建库至2023年11月18日的相关文献。文献主题为比较TIVA和IA对接受结直肠癌切除术患者预后的影响。
选择6项研究进行荟萃分析。这些研究涉及111043例患者，试验规模为1001 - 88184人。接受TIVA和IA的结直肠癌患者的总生存期（OS）存在统计学显著差异（风险比[HR]，0.83；95%置信区间[CI]，0.70 - 0.99），但无病生存期（RFS）无差异（HR，0.99；95% CI，0.90 - 1.08）。在OS的亚组分析中，亚洲接受TIVA和IA的结直肠癌患者之间未观察到统计学显著差异（HR，0.77；95% CI，0.57 - 1.05），欧洲也未观察到（HR，0.99；95% CI，0.93 - 1.06）。关于肿瘤位置，在结肠、直肠和结直肠中TIVA和IA之间未发现显著关联（（HR，0.70；95% CI，0.38 - 1.28）、（HR，0.95；95% CI，0.83 - 1.08）和（HR，0.99；95% CI，0.93 - 1.06））。
接受结直肠癌切除术的患者中，接受TIVA和IA的患者OS存在显著差异，但RFS无差异。TIVA和IA的预后影响不同。
https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023453185，标识符CRD42023453185。
