Mohammadi Mohammad Reza, Ahmadi Ameneh, Karimi Reza, Hooshyari Zahra
Psychiatry and Psychology Research Center, Roozbeh Hospital, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Department of Clinical Psychology, Roozbeh Hospital, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Iran J Psychiatry. 2024 Feb;19(2):229-237. doi: 10.18502/ijps.v19i2.15109.
Psychosis is one of the most vital disorders in children and youths. The definite pathophysiology of schizophrenia and other psychotic disorders in the growth period has remained ambiguous. Therefore, the purpose of the current study was to investigate the predictive value of parental psychiatric disorders and the mediator role of comorbid disorders of children and youths. The sample, consisting of 29884 individuals aged between 6 to 18 years old from the Iranian population, were selected by multistage cluster sampling during September 22, 2016 to January 3, 2018. Parents were requested to complete a survey around their potential psychiatric disorders, based on their Millon's Clinical Multiaxial Inventory-III (MCMI-III). The Semi-Structured Interview (Kiddie-SADS-Present, Lifetime Form (K-SADS-PL)) was utilized to analyze psychiatric disorders concurring to the DSM. The fit indices of the model show that the research model has a good fit and the psychiatric disorders of parents directly and indirectly through comorbid disorders are effective on the psychosis symptoms of children and adolescents (RMSEA=0.06, CFI=0.89, PGFI=0.75, PNFI=0.75).The incidence of Schizotypal Personality Disorder, Anxiety, Bipolar Spectrum Disorder, PTSD, Schizophrenia Spectrum and Delusional Disorder were statistically higher in parents of psychotic children and adolescents. However, Borderline Personality Disorder was more frequent among their mothers while Alcohol Dependency and Drug Dependency were significantly more prevalent among their fathers. The outcomes of our study showed that there were statistically significant differences between the mean scores of each scale assessed by Millon's inventory between parents of psychotic versus non-psychotic pediatric cases. In addition, psychiatric disorders were more common among children and youths with psychosis spectrum in comparison with the general population.
精神病是儿童和青少年中最重要的疾病之一。儿童和青少年时期精神分裂症及其他精神疾病的确切病理生理学仍不明确。因此，本研究的目的是探讨父母精神疾病的预测价值以及儿童和青少年共病的中介作用。研究样本来自伊朗人群，通过多阶段整群抽样选取了29884名6至18岁的个体，选取时间为2016年9月22日至2018年1月3日。要求父母根据米隆临床多轴问卷第三版（MCMI-III）完成一份关于他们潜在精神疾病的调查。采用半结构式访谈（儿童版情感障碍和精神分裂症问卷，现患、终生版（K-SADS-PL））来分析符合《精神疾病诊断与统计手册》的精神疾病。模型的拟合指数表明，该研究模型拟合良好，父母的精神疾病通过共病直接或间接地对儿童和青少年的精神病症状有影响（近似误差均方根RMSEA=0.06，比较拟合指数CFI=0.89，简约拟合指数PGFI=0.75，增值拟合指数PNFI=0.75）。患有精神病的儿童和青少年的父母中，分裂型人格障碍、焦虑症、双相谱系障碍、创伤后应激障碍、精神分裂症谱系和妄想障碍的发病率在统计学上更高。然而，边缘型人格障碍在他们的母亲中更为常见，而酒精依赖和药物依赖在他们的父亲中明显更为普遍。我们的研究结果表明，在患有精神病与未患精神病的儿科病例的父母中，米隆问卷评估的各量表平均得分在统计学上存在显著差异。此外，与普通人群相比，患有精神病谱系的儿童和青少年中精神疾病更为常见。
