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微妙的平衡：水消毒和副产物免疫毒性。

A Delicate Balance: Water Disinfection and By-Product Immunotoxicity.

出版信息

Environ Health Perspect. 2024 Apr;132(4):44004. doi: 10.1289/EHP14529. Epub 2024 Apr 30.

DOI:10.1289/EHP14529
PMID:38687630
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11060424/
Abstract

Mouse macrophages and human blood cells exposed to very high levels of three trihalophenols showed changes in RNA methylation, pointing to one mechanism by which disinfection by-products may harm health, even as disinfection protects it in other ways.

摘要

当三卤甲烷暴露在非常高的浓度下时，实验用小白鼠的巨噬细胞和人类的血细胞中的 RNA 甲基化发生了改变，这指向了一个消毒副产物可能有害健康的机制，即使消毒以其他方式保护了健康。

相似文献

1
A Delicate Balance: Water Disinfection and By-Product Immunotoxicity.微妙的平衡：水消毒和副产物免疫毒性。
Environ Health Perspect. 2024 Apr;132(4):44004. doi: 10.1289/EHP14529. Epub 2024 Apr 30.
2
Genotoxicity of drinking water treated with different disinfectants and effects of disinfection conditions detected by umu-test.用umu试验检测不同消毒剂处理的饮用水的遗传毒性及消毒条件的影响。
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本文引用的文献

1
Immunotoxicity Evaluation of Trihalophenolic Disinfection By-Products in Mouse and Human Mononuclear Macrophage Systems: The Role of RNA Epitranscriptomic Modification in Mammalian Immunity.三卤酚类消毒副产物的免疫毒性评价：在小鼠和人单核巨噬细胞系统中，RNA 表观转录组修饰在哺乳动物免疫中的作用。
Environ Health Perspect. 2023 Dec;131(12):127023. doi: 10.1289/EHP11329. Epub 2023 Dec 29.
2
Optimizing disinfectant residual dosage in engineered water systems to minimize the overall health risks of opportunistic pathogens and disinfection by-products.优化工程水系统中的消毒剂残留剂量，以尽量降低机会性病原体和消毒副产物的总体健康风险。
Sci Total Environ. 2021 May 20;770:145356. doi: 10.1016/j.scitotenv.2021.145356. Epub 2021 Jan 23.
3
The role of m6A modification in the biological functions and diseases.m6A 修饰在生物学功能和疾病中的作用。
Signal Transduct Target Ther. 2021 Feb 21;6(1):74. doi: 10.1038/s41392-020-00450-x.
4
Environmental pollutants and the immune response.环境污染物与免疫应答。
Nat Immunol. 2020 Dec;21(12):1486-1495. doi: 10.1038/s41590-020-0802-6. Epub 2020 Oct 12.
5
Formation and interdependence of disinfection byproducts during chlorination of natural organic matter in a conventional drinking water treatment plant.在常规饮用水处理厂中，氯消毒天然有机物过程中消毒副产物的形成与相互关系。
Chemosphere. 2020 Mar;242:125227. doi: 10.1016/j.chemosphere.2019.125227. Epub 2019 Oct 31.
6
Application of (LC/)MS/MS precursor ion scan for evaluating the occurrence, formation and control of polar halogenated DBPs in disinfected waters: A review.（LC/MS/MS）前体离子扫描在评估消毒水中极性卤代 DBPs 的发生、形成和控制中的应用：综述。
Water Res. 2019 Jul 1;158:322-337. doi: 10.1016/j.watres.2019.04.033. Epub 2019 Apr 22.
7
Macrophage plasticity, polarization, and function in health and disease.巨噬细胞的可塑性、极化及其在健康与疾病中的功能。
J Cell Physiol. 2018 Sep;233(9):6425-6440. doi: 10.1002/jcp.26429. Epub 2018 Mar 1.
8
Drinking Water Disinfection Byproducts (DBPs) and Human Health Effects: Multidisciplinary Challenges and Opportunities.饮用水消毒副产物（DBPs）与人体健康效应：多学科的挑战与机遇。
Environ Sci Technol. 2018 Feb 20;52(4):1681-1689. doi: 10.1021/acs.est.7b05440. Epub 2018 Jan 21.
9
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Water Res. 2017 Apr 1;112:129-136. doi: 10.1016/j.watres.2017.01.037. Epub 2017 Jan 24.
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Epidemiology and Ecology of Opportunistic Premise Plumbing Pathogens: Legionella pneumophila, Mycobacterium avium, and Pseudomonas aeruginosa.机会性建筑物管道病原体的流行病学与生态学：嗜肺军团菌、鸟分枝杆菌和铜绿假单胞菌
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