Almeida Mariana Bortholazzi, Galdiano Caio Menezes Ribeiro, Silva Benvenuto Filipe Sampaio Reis da, Carrilho Emanuel, Brazaca Laís Canniatti
Instituto de Química de São Carlos, Universidade de São Paulo, São Carlos, São Paulo 13566-590, Brazil.
Instituto Nacional de Ciência e Tecnologia de Bioanalítica-INCTBio, Campinas, São Paulo 13083-970, Brazil.
ACS Appl Mater Interfaces. 2024 Dec 11;16(49):67054-67072. doi: 10.1021/acsami.4c00838. Epub 2024 Apr 30.
The applicability of nanomaterials has evolved in biomedical domains thanks to advances in biocompatibility strategies and the mitigation of cytotoxic effects, allowing diagnostics, imaging, and therapeutic approaches. The application of nanoparticles (NP), particularly metal nanoparticles (mNPs), such as gold (Au) and silver (Ag), includes inherent challenges related to the material characteristics, surface modification, and bioconjugation techniques. By tailoring the surface properties through appropriate coating with biocompatible molecules or functionalization with active biomolecules, researchers can reach a harmonious interaction with biological systems or samples (mostly fluids or tissues). Thus, this review highlights the mechanisms associated with the obtention of biocompatible mNP and presents a comprehensive overview of methods that facilitate safe and efficient production. Therefore, we consider this review to be a valuable resource for all researchers navigating this dynamic field.
由于生物相容性策略的进步和细胞毒性作用的减轻，纳米材料在生物医学领域的适用性得到了发展，从而实现了诊断、成像和治疗方法。纳米颗粒（NP）的应用，特别是金属纳米颗粒（mNP），如金（Au）和银（Ag），包括与材料特性、表面改性和生物共轭技术相关的固有挑战。通过用生物相容性分子进行适当的涂层或用活性生物分子进行功能化来调整表面性质，研究人员可以与生物系统或样品（主要是流体或组织）实现和谐的相互作用。因此，本综述强调了与获得生物相容性mNP相关的机制，并全面概述了有助于安全高效生产的方法。因此，我们认为本综述对所有在这个动态领域中探索的研究人员来说都是一个有价值的资源。
