Department of General Surgery, Center of Gastrointestinal and Minimally Invasive Surgery, The Third People's Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University & The Second Affiliated Hospital of Chengdu, Chongqing Medical University, Chengdu, Sichuan, China; Institute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu, Sichuan, China.
Institute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu, Sichuan, China.
Int Dent J. 2024 Oct;74(5):1033-1043. doi: 10.1016/j.identj.2024.03.019. Epub 2024 Apr 30.
Periodontitis, a chronic inflammatory condition affecting the supporting structures of the teeth, is a substantial public health burrden whilst impacting the life quality of those affected. Elevated levels of systemic immune-inflammation index (SII) and systemic inflammation response index (SIRI) have been implicated in various inflammatory conditions. This study aimed to investigate the relationship between SII and SIRI with periodontitis.
The study examined a total of 8666 participants in the 2009 to 2014 National Health and Nutrition Examination Survey (NHANES). The study compared the weighted prevalence of periodontitis among various groups. The association between SII, SIRI levels, and periodontitis was analyzed using binary logistic regression. Additionally, we explored nonlinear relationships between SII, SIRI, and the prevalence of periodontitis using restricted cubic spline (RCS) plots.
Among participants in the fourth quartile (Q4) of SII and SIRI, the highest prevalence of periodontitis was observed, with rates of 44.87% and 48.41%, respectively. After adjusting for all covariates, the odds ratio (OR) for periodontitis associated with SII Q4 was 1.19 (95% CI 1.02, 1.39, P = .03), while for SIRI Q4, it was 1.18 (95% CI 1.01, 1.39, P = .04). In addition, the results of sensitivity analysis revealed consistent findings, indicating that after adjusting for all covariates, the OR for periodontitis associated with SII Q4 and SIRI Q4 remained statistically significant. Specifically, the OR for periodontitis associated with SII Q4 was 1.19 (95% CI 1.02, 1.39, P = .03), while for SIRI Q4, it was 1.19 (95% CI 1.01, 1.40, P = .04).
These results indicate that elevated SII and SIRI levels are associated with an increased prevalence of periodontitis.
These findings suggest a potential connection between systemic inflammation and periodontitis, highlighting the importance of periodontitis patients being aware of their systemic diseases that are inflammatory in nature such as chronic cardiovascular afflictions.
牙周炎是一种慢性炎症性疾病，影响牙齿的支持结构，是一种严重的公共卫生负担，同时影响受影响人群的生活质量。全身性免疫炎症指数（SII）和全身性炎症反应指数（SIRI）水平升高与各种炎症性疾病有关。本研究旨在探讨 SII 和 SIRI 与牙周炎的关系。
本研究共纳入了 2009 年至 2014 年全国健康与营养调查（NHANES）中的 8666 名参与者。研究比较了不同组别的牙周炎加权患病率。使用二元逻辑回归分析 SII、SIRI 水平与牙周炎之间的关联。此外，我们还使用限制性立方样条（RCS）图探索了 SII、SIRI 与牙周炎患病率之间的非线性关系。
在 SII 和 SIRI 第四四分位数（Q4）的参与者中，观察到牙周炎的最高患病率，分别为 44.87%和 48.41%。在调整所有协变量后，SII Q4 与牙周炎相关的比值比（OR）为 1.19（95%CI 1.02，1.39，P =.03），而 SIRI Q4 的 OR 为 1.18（95%CI 1.01，1.39，P =.04）。此外，敏感性分析的结果显示出一致的发现，表明在调整所有协变量后，SII Q4 和 SIRI Q4 与牙周炎相关的 OR 仍然具有统计学意义。具体而言，SII Q4 与牙周炎相关的 OR 为 1.19（95%CI 1.02，1.39，P =.03），而 SIRI Q4 的 OR 为 1.19（95%CI 1.01，1.40，P =.04）。
这些结果表明，SII 和 SIRI 水平升高与牙周炎的患病率增加有关。
这些发现提示全身性炎症与牙周炎之间存在潜在联系，强调了牙周炎患者意识到自己患有慢性心血管疾病等炎症性系统性疾病的重要性。
