Department of Surgery, TAYS Cancer Center, Tampere, Finland.
Department of Surgery, Tampere University Hospital, Elämänaukio 2, PL 2000, 33521, Tampere, Finland.
Sci Rep. 2024 Apr 30;14(1):9943. doi: 10.1038/s41598-024-60451-6.
We evaluated whether previous inguinal hernia repair may affect the choice of prostate carcinoma treatment in a population-based cohort. It has been suggested that previous laparoscopic inguinal hernia repair (LIHR) could limit the subsequent possibility of performing a prostatectomy. Several small studies have suggested otherwise. The study cohort included all new prostate cancer cases in Finland 1998-2015 identified through the Finnish cancer registry. Data on the treatment of prostate cancer and surgical inguinal hernia repairs in 1998-2016 was obtained from the HILMO hospital discharge registry. After linkage, the study cohort included 7206 men. Of these, 5500 had no history of inguinal hernia, 1463 had an open hernia repair, and 193 had a minimally invasive repair (LIHR). Compared to men with no history of hernia repair, those with previous hernia repairs were more likely to undergo prostatectomy over radiation therapy as the primary treatment for prostate cancer HR 1.34 (CI 95% 1.19-1.52). The association did not depend on the method of hernia repair, HR 1.58 (CI 95% 1.15-2.18), in men with previous LIHR. The increased likelihood of choosing prostatectomy over radiation therapy concerns all type prostatectomies. Previous hernia repair is not a limiting factor when choosing treatment for prostate cancer.
我们评估了既往腹股沟疝修补术是否会影响基于人群的队列中前列腺癌治疗的选择。有人认为，既往腹腔镜腹股沟疝修补术（LIHR）可能会限制随后进行前列腺切除术的可能性。几项小型研究结果则相反。研究队列包括芬兰 1998-2015 年所有新诊断的前列腺癌病例，这些病例通过芬兰癌症登记处确定。1998-2016 年前列腺癌治疗和手术性腹股沟疝修补的数据从 HILMO 医院出院登记处获得。链接后，研究队列包括 7206 名男性。其中，5500 名男性无腹股沟疝史，1463 名男性接受开放性疝修补术，193 名男性接受微创修复术（LIHR）。与无疝修补史的男性相比，既往疝修补术的男性更有可能选择前列腺切除术作为前列腺癌的主要治疗方法，HR 为 1.34（95%CI 1.19-1.52）。该关联与疝修补术的方法无关，LIHR 前 HR 为 1.58（95%CI 1.15-2.18）。选择前列腺切除术而非放疗的可能性增加，涉及所有类型的前列腺切除术。既往疝修补术不是选择前列腺癌治疗的限制因素。
