Editorial: Novel insights connecting telomere biology to cancer development and progression.
作者信息
Khattar Ekta, Salvati Erica
机构信息
Sunandan Divatia School of Science, SVKM's NMIMS (Deemed to be) University, Mumbai, India.
Institute of Molecular Biology and Pathology, National Research Council, Rome, Italy.
出版信息
Front Oncol. 2024 Apr 16;14:1405618. doi: 10.3389/fonc.2024.1405618. eCollection 2024.
Abstract
摘要
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Role of Telomeres and Telomeric Proteins in Human Malignancies and Their Therapeutic Potential.端粒和端粒蛋白在人类恶性肿瘤中的作用及其治疗潜力
Cancers (Basel). 2020 Jul 14;12(7):1901. doi: 10.3390/cancers12071901.
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CTC1-STN1 terminates telomerase while STN1-TEN1 enables C-strand synthesis during telomere replication in colon cancer cells.在结直肠癌细胞中端粒酶复制过程中，CTC1-STN1 终止端粒酶，而 STN1-TEN1 则使 C 链合成成为可能。
Nat Commun. 2018 Jul 19;9(1):2827. doi: 10.1038/s41467-018-05154-z.
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CTC1-STN1 coordinates G- and C-strand synthesis to regulate telomere length.CTC1-STN1 协调 G- 和 C-链合成以调节端粒长度。
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CTC1-mediated C-strand fill-in is an essential step in telomere length maintenance.CTC1介导的C链填补是端粒长度维持的关键步骤。
Nucleic Acids Res. 2017 May 5;45(8):4281-4293. doi: 10.1093/nar/gkx125.
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Structure of the human telomeric Stn1-Ten1 capping complex.人端粒 Stn1-Ten1 加帽复合物的结构。
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Human CST has independent functions during telomere duplex replication and C-strand fill-in.人类 CST 在端粒双链复制和 C 链填充过程中具有独立功能。
Cell Rep. 2012 Nov 29;2(5):1096-103. doi: 10.1016/j.celrep.2012.10.007. Epub 2012 Nov 8.
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The human CST complex is a terminator of telomerase activity.人类 CST 复合物是端粒酶活性的终结者。
Nature. 2012 Aug 23;488(7412):540-4. doi: 10.1038/nature11269.
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Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1.TRF2和POT1通过对ATM和ATR的独立调控来保护端粒。
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Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines.人类肿瘤及肿瘤衍生细胞系中维持端粒长度的另一种机制的证据。
Nat Med. 1997 Nov;3(11):1271-4. doi: 10.1038/nm1197-1271.
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Identification of a specific telomere terminal transferase activity in Tetrahymena extracts.在四膜虫提取物中鉴定出一种特定的端粒末端转移酶活性。
Cell. 1985 Dec;43(2 Pt 1):405-13. doi: 10.1016/0092-8674(85)90170-9.
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