Department of Periodontology, Faculty of Dentistry, Ankara Medipol University, Ankara, Turkey.
Department of Periodontology, Faculty of Dentistry, Gazi University, Ankara, Turkey.
Clin Oral Investig. 2024 May 1;28(5):290. doi: 10.1007/s00784-024-05692-5.
Psychological stress has been identified in some observational studies as a potential factor that may modify and affect periodontal diseases, but there are no similar data for peri-implantitis. The aim of this study was to determine the relationship between interleukin (IL)-1β, IL-6, IL-10, interferon (IFN)α inflammatory cytokines and the psychological stress-related markers, glucocorticoid receptor-α (GRα), and salivary α-amylase (sAA) gene expression levels in saliva samples obtained from healthy implants and peri-implantitis patients.
The study included a total of 50 systemically healthy subjects. Peri-implant clinical parameters were recorded and psychological stress level was evaluated with the hospital anxiety and depression scale (HAD) and state-trait anxiety inventory (STAI) questionnaire forms. Following the evaluations, the patients were divided into 4 groups according their stress and clinical status (Ia, Ib, IIa, IIb). IL-1β, IL-6, IL-10, IFNα, GRα, sAA gene expression levels in the saliva samples were quantified by quantitative polymerase chain reaction (qPCR).
In the group of peri-implantitis who had a high score in stress level assessment scales, significantly higher IL-1β, IL-6, sAA expression levels were observed (p < 0.001). The IL-10 gene expression levels were lower in the groups with a high score in the stress level assessment scales (p < 0.001). GRα gene was expressed at lower levels in the group of peri-implantitis who had a high score in stress level assessment scales but the difference was not statistically significant (p = 0.065).
The study findings suggest that psychological stress may increase the inflammation associated with peri-implantitis by affecting cytokine expression levels.
To prevent peri-implantitis or reduce its prevalence, it could be beneficial to evaluate stress levels and identify individuals experiencing stress.
一些观察性研究表明，心理压力是可能改变和影响牙周疾病的潜在因素，但对于种植体周围炎尚无类似数据。本研究旨在确定白细胞介素（IL）-1β、IL-6、IL-10、干扰素（IFN）α 炎性细胞因子与唾液中糖皮质激素受体-α（GRα）和唾液α-淀粉酶（sAA）基因表达水平之间的关系，这些细胞因子和基因表达水平来自于健康种植体和种植体周围炎患者的唾液样本。
本研究共纳入 50 例系统性健康受试者。记录种植体周围临床参数，并采用医院焦虑抑郁量表（HAD）和状态特质焦虑量表（STAI）问卷形式评估心理压力水平。评估后，根据患者的压力和临床状况将其分为 4 组（Ia、Ib、IIa、IIb）。采用实时定量聚合酶链反应（qPCR）定量检测唾液样本中 IL-1β、IL-6、IL-10、IFNα、GRα、sAA 基因的表达水平。
在压力评分量表中得分较高的种植体周围炎组中，观察到 IL-1β、IL-6、sAA 表达水平显著升高（p<0.001）。在压力评分量表中得分较高的组中，IL-10 基因表达水平较低（p<0.001）。在压力评分量表中得分较高的种植体周围炎组中，GRα 基因表达水平较低，但差异无统计学意义（p=0.065）。
研究结果表明，心理压力可能通过影响细胞因子表达水平，增加与种植体周围炎相关的炎症。
为了预防种植体周围炎或降低其患病率，评估压力水平并识别压力较大的个体可能会有所帮助。
