Department of Prosthetic Dental Sciences, College of Dentistry, King Saud University, Riyadh, Saudi Arabia.
Department of Cardiac Sciences, King Fahad Cardiac Center, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Clin Implant Dent Relat Res. 2019 Dec;21(6):1218-1224. doi: 10.1111/cid.12866. Epub 2019 Nov 11.
There are no studies that have evaluated the correlation between self-rated pain, peri-implant clinical and radiographic parameters (plaque index [PI], bleeding on probing [BOP], probing depth [PD], and crestal bone loss [CBL]) and whole salivary interleukin (IL)-1β, IL-6, and tumor necrosis factor-alpha (TNF-α) levels among patients with and without peri-implantitis.
The objective was to evaluate the correlation between self-evaluated pain, peri-implant clinical and radiographic parameters and whole salivary IL-1β, IL-6, and TNF-α levels among patients with and without peri-implantitis.
Included in this study were patients with and without peri-implantitis. Data regarding age, gender, duration of implants in function, and self-perceived pain were recorded using a question. Self-rated pain was assessed using the numeric pain rating scale. Peri-implant PD, PI, BOP, and CBL were recorded and samples of unstimulated whole saliva samples were obtained. Whole salivary IL-1β, IL-6, and TNF-α were measured. Sample-size was approximated and group comparisons were completed. P-values <.05 were regarded as statistically significant.
Forty-six male individuals (21 with and 25 without peri-implantitis) were included. The mean age of individuals with and without PiD was 53.71 ± 5.45 and 50.92 ± 6.26 years, respectively. The mean self-rated pain score in patients with and without PiD was 3 ± 2 and zero, respectively. There was no significant difference in the SFR among patients with and without peri-implantitis. Levels of IL-1β (P < .01), IL-6 (P < .01), and TNF-α (P < .01) were significantly elevated in subjects with than without peri-implantitis. Regression analysis-based results reflected no significant association between increasing self-rated pain and whole salivary IL-1β, IL-6, and TNF-α levels.
Proinflammatory cytokines (IL-1β, IL-6, and TNF-α) are more often expressed in the UWS of patients with than without peri-implantitis. However, the correlation between self-rated pain and whole salivary proinflammatory cytokine profile in patients with peri-implantitis remains unclear.
目前尚无研究评估有和无种植体周围炎患者的自我评估疼痛、种植体周围临床和影像学参数（菌斑指数[PI]、探诊出血[BOP]、探诊深度[PD]和种植体边缘骨丧失[CBL]）与全唾液白细胞介素（IL）-1β、IL-6 和肿瘤坏死因子-α（TNF-α）水平之间的相关性。
本研究旨在评估有和无种植体周围炎患者的自我评估疼痛、种植体周围临床和影像学参数与全唾液 IL-1β、IL-6 和 TNF-α水平之间的相关性。
本研究纳入了有和无种植体周围炎的患者。使用问卷记录了年龄、性别、种植体使用时间和自我感知疼痛等数据。使用数字疼痛评分量表评估自我评估疼痛。记录种植体 PD、PI、BOP 和 CBL，并采集非刺激全唾液样本。测量全唾液中的 IL-1β、IL-6 和 TNF-α。根据样本量进行近似，并完成组间比较。P 值<.05 被认为具有统计学意义。
共纳入 46 名男性个体（21 名有种植体周围炎，25 名无种植体周围炎）。有和无种植体周围炎个体的平均年龄分别为 53.71±5.45 岁和 50.92±6.26 岁。有和无种植体周围炎个体的自我评估疼痛评分均值分别为 3±2 分和 0 分。有和无种植体周围炎个体的 SFR 无显著差异。与无种植体周围炎患者相比，种植体周围炎患者的 IL-1β（P<.01）、IL-6（P<.01）和 TNF-α（P<.01）水平显著升高。基于回归分析的结果表明，自我评估疼痛增加与全唾液 IL-1β、IL-6 和 TNF-α水平之间无显著相关性。
与无种植体周围炎患者相比，种植体周围炎患者的 UWS 中更常表达促炎细胞因子（IL-1β、IL-6 和 TNF-α）。然而，种植体周围炎患者自我评估疼痛与全唾液促炎细胞因子谱之间的相关性仍不清楚。
