2022 年 6 月在 COVID-19 防控下广州市流感流行情况分析。

Analysis of the epidemiological situation of influenza in Guangzhou under the prevention and control of COVID-19 in June 2022.

机构信息

Department of Laboratory Medicine, The Key Laboratory of Advanced Interdisciplinary Studies Center, The First Affiliated Hospital of Guangzhou Medical University, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, Guangzhou, China.

National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China.

出版信息

Clin Respir J. 2024 May;18(5):e13754. doi: 10.1111/crj.13754.

DOI:10.1111/crj.13754

PMID:38693702

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11063456/

Abstract

OBJECTIVE

Under the prevention and control measures of COVID-19, the epidemiological situation of respiratory pathogens is not well known. Understanding the patterns of respiratory pathogens epidemiology under the prevention and control measures of COVID-19 is important to guide resource allocation for existing and future treatment and prevention strategies.

METHODS

In total, 659 fever outpatients nasopharyngeal swabs were collected at fever illness onset during June in 2022 at the First Hospital of Guangzhou Medical University. Swabs were tested by real-time fluorescent single-tube multiplex polymerase chain reaction (PCR) for 12 respiratory pathogens. Moreover, 108 of the 659 swabs were tested for influenza virus antigen.

RESULTS

At least one pathogen was detected in 477 (72.38%) of 659 fever outpatients with multiple pathogens identified in 25 (3.79%). The highest multiple infectious pattern is parainfluenza virus in combination with influenza (five cases). Influenza A virus (IFA), human rhinovirus (HRV), and parainfluenza virus are the three leading virus pathogens with proportions of 64.64%, 5.01%, and 2.88%. School-age children and adult groups have the highest pathogens positivity rate of 81.28% and 83.87%.

CONCLUSION

A high proportion of adolescents and adults has respiratory pathogens detected during fever illnesses during June in 2022 under the prevention and control of COVID-19. These data indicate that diagnosis, prevention, and control of respiratory tract infection should be paid attention under the prevention and control of COVID-19.

摘要

目的

在 COVID-19 防控措施下，呼吸道病原体的流行情况尚不清楚。了解 COVID-19 防控措施下呼吸道病原体的流行病学模式对于指导现有和未来治疗和预防策略的资源分配非常重要。

方法

2022 年 6 月，在广州医科大学第一附属医院，共采集了 659 例发热门诊患者的鼻咽拭子。采用实时荧光单管多重聚合酶链反应（PCR）检测 12 种呼吸道病原体。此外，对 659 份拭子中的 108 份进行了流感病毒抗原检测。

结果

在 659 例发热患者中，至少有 1 种病原体被检测到，477 例（72.38%）患者存在多种病原体，25 例（3.79%）患者存在多重感染。最高的多重感染模式是副流感病毒与流感病毒联合感染（5 例）。甲型流感病毒（IFA）、人类鼻病毒（HRV）和副流感病毒是三种主要的病毒病原体，其比例分别为 64.64%、5.01%和 2.88%。学龄儿童和成年组的病原体阳性率最高，分别为 81.28%和 83.87%。