Warren Alison
The Department of Clinical Research and Leadership, George Washington University School of Medicine and Health Sciences, Washington, DC, United States.
Front Aging Neurosci. 2024 Apr 17;16:1395825. doi: 10.3389/fnagi.2024.1395825. eCollection 2024.
Neurocognitive decline is one of the foremost dire issues in medicine today. The mechanisms by which dementia pathogenesis ensues are complicated and multifactorial, particularly in the case of Alzheimer's disease (AD). One irrefutable, yet unexplained factor is the gender disparity in AD, in which women are disproportionately affected by AD, both in the rate and severity of the disease. Examining the multifaceted contributing causes along with unique gender dynamics in modifiable risk factors, such as diet, may lend some insight into why this disparity exists and potential paths forward. The aim of this brief narrative review is to summarize the current literature of gender differences in dietary habits and how they may relate to neuroinflammatory states that contribute to AD pathogenesis. As such, the interplay between diet, hormones, and inflammation will be discussed, along with potential interventions to inform care practices.
神经认知衰退是当今医学领域最严峻的问题之一。痴呆症发病的机制复杂且多因素，尤其是在阿尔茨海默病（AD）的情况下。一个无可争议但尚未得到解释的因素是AD中的性别差异，即女性在该疾病的发病率和严重程度方面受到的影响不成比例。研究可改变风险因素（如饮食）中多方面的促成原因以及独特的性别动态，可能有助于深入了解这种差异存在的原因以及潜在的前进方向。这篇简短的叙述性综述的目的是总结当前关于饮食习惯性别差异的文献，以及它们如何与导致AD发病机制的神经炎症状态相关。因此，将讨论饮食、激素和炎症之间的相互作用，以及为护理实践提供信息的潜在干预措施。
