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香科科属植物:文献中新增的毒性作用:一例病例报告

Teucrium polium: new toxic effects added to the literature: a case report.

作者信息

Ghassa Ali, Ismail Mousa, Alani Leen Alabd Alrazak

机构信息

Faculty of Medicine, Damascus University.

Department of Cardiology.

出版信息

Ann Med Surg (Lond). 2024 Jan 25;86(5):3005-3008. doi: 10.1097/MS9.0000000000001760. eCollection 2024 May.

Abstract

INTRODUCTION AND IMPORTANCE

Teucrium polium is one of the aromatic plants that grows in the Mediterranean region, and had been used as an herbal treatment for diabetes due to its hypoglycaemia effect. Although this plant is being studied now for its therapeutic role, its side effects are not taken enough into consideration, so this unique case can shed the light on serious toxic effects of this plant.

CASE PRESENTATION

A 68-year-old woman presented to the hospital with generalized fatigue, malaise, nausea, vomiting, abdominal pain, polydipsia, polyuria, breathlessness, and no defecation for 2 days after drinking big amounts of teucrium polium. The diagnosis was diabetic ketoacidosis (DKA), complete heart block, acute liver and kidney damage, and urinary tract infection (UTI). The patient was admitted to the ICU and treated for the DKA with an insulin pump, an antibiotic treatment for UTI, in addition to a dopamine pump and atropine, and then a temporary pacemaker was placed. The patient's DKA, liver and kidney damage were improved on day 9, heart rate returned normal and she was discharged to insert a permanent pacemaker. However, the patient passed away at the end.

CLINICAL DISCUSSION

Most studies made on this plant focused on the hypoglycaemia effect, with no attention to its toxic effects, so only few studies showed that teucrium polium can cause hepatic, renal toxicity and hyperglycaemia and most of them were studied in animals. While cardiac toxicity has never been noticed before.

CONCLUSION

For this reason, herbal treatment should be used with caution to avoid catastrophic side effects.

摘要

引言与重要性

夏香薄荷是生长在地中海地区的芳香植物之一,因其降血糖作用而被用作糖尿病的草药治疗。尽管目前正在研究这种植物的治疗作用,但其副作用并未得到足够重视,因此这个独特的病例可以揭示这种植物的严重毒性作用。

病例介绍

一名68岁女性因大量饮用夏香薄荷后出现全身乏力、不适、恶心、呕吐、腹痛、烦渴、多尿、呼吸急促且2天未排便而入院。诊断为糖尿病酮症酸中毒(DKA)、完全性心脏传导阻滞、急性肝肾功能损害和尿路感染(UTI)。患者被收入重症监护病房,使用胰岛素泵治疗DKA,使用抗生素治疗UTI,此外还使用了多巴胺泵和阿托品,随后植入了临时起搏器。患者的DKA、肝肾功能损害在第9天有所改善,心率恢复正常,她出院去植入永久性起搏器。然而,患者最终去世。

临床讨论

大多数关于这种植物的研究都集中在降血糖作用上,而没有关注其毒性作用,因此只有少数研究表明夏香薄荷会导致肝、肾毒性和高血糖,而且大多数研究是在动物身上进行的。而心脏毒性此前从未被注意到。

结论

因此,使用草药治疗时应谨慎,以避免灾难性的副作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0e4/11060313/803e5675ea35/ms9-86-3005-g001.jpg

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