Faa Gavino, Cau Riccardo, Ravarino Alberto, Canino Andrea, Van Eyken Peter, Fraschini Matteo, Suri Jasjit S, Saba Luca
Department of Medical Sciences, University of Cagliari, Cagliari, Italy.
Department of Biology, College of Science and Technology, Temple University, Philadelphia, PA, USA.
J Public Health Res. 2024 May 1;13(2):22799036241249659. doi: 10.1177/22799036241249659. eCollection 2024 Apr.
Atherosclerosis is a complex disease characterized by the accumulation of plaques in arterial walls. Understanding its pathogenesis remains incomplete, with factors like inflammation, oxidative stress, and hypertension playing critical roles. The disease exhibits preferential localization of plaques, with variability observed even within the same individual. Genetic, environmental, and lifestyle factors contribute to its heterogeneity. Histological plaque phenotypes vary widely, prompting classification schemes focusing on systemic and local factors deteriorating fibrous caps. Recent research highlights differences in plaque histology among arterial systems, suggesting unique pathophysiological mechanisms. This study reports on multiple atherosclerotic plaques detected at autopsy in various vascular sites of a single subject, emphasizing their histological diversity and underscoring the systemic nature of atherosclerosis.
动脉粥样硬化是一种复杂的疾病，其特征是动脉壁上出现斑块堆积。对其发病机制的理解仍不完整，炎症、氧化应激和高血压等因素起着关键作用。该疾病表现出斑块的优先定位，甚至在同一个体内也存在变异性。遗传、环境和生活方式因素导致了其异质性。组织学斑块表型差异很大，促使人们制定关注系统性和局部因素导致纤维帽恶化的分类方案。最近的研究突出了不同动脉系统之间斑块组织学的差异，表明存在独特的病理生理机制。本研究报告了在一名受试者的多个血管部位尸检时检测到的多个动脉粥样硬化斑块，强调了它们的组织学多样性，并强调了动脉粥样硬化的系统性本质。
