State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.
State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.
Clin Chim Acta. 2022 Jun 1;531:217-222. doi: 10.1016/j.cca.2022.04.012. Epub 2022 Apr 14.
Atherosclerosis is a disease in which the arterial intima thickens and transforms into a sclerotic plaque, interfering with normal blood flow and potentially leading to stroke or death. It is divided into three stages: the pre-stage, which is characterized by diffuse intimal thickenings (DITs) and fatty streaks, the early atherosclerotic stage, which is characterized by pathological intimal thickening (PIT), and the late stage, which is characterized by fibroatheromas transformed from PIT. Each stage of atherosclerosis is distinguished by distinct morphological changes, biological changes, and the expression of immune markers at various levels. This review summarizes discoveries and achievements in microanatomy, ultrastructure, immunohistochemical staining, and molecular biology in the literature on atherosclerosis. Based on our research, we have emphasized common histological changes and pathological mechanisms of atherosclerosis in this review.
动脉粥样硬化是一种疾病，其特征为动脉内膜增厚并转化为硬化斑块，干扰正常血流并可能导致中风或死亡。它分为三个阶段：前阶段，其特征为弥漫性内膜增厚（DIT）和脂肪条纹；早期动脉粥样硬化阶段，其特征为病理性内膜增厚（PIT）；晚期阶段，其特征为 PIT 转化而来的纤维粥样瘤。动脉粥样硬化的每个阶段都有不同的形态变化、生物学变化和不同水平免疫标志物的表达。本综述总结了动脉粥样硬化文献中在微观解剖学、超微结构、免疫组织化学染色和分子生物学方面的发现和成就。基于我们的研究，我们在本综述中强调了动脉粥样硬化的常见组织学变化和病理机制。
