Hu Tingting, Zhang Ying, Chen Zhu, Su Jun
Department of Clinical Laboratory, Hangzhou Women's Hospital (Hangzhou Maternity and Child Health Care Hospital), Hangzhou, Zhejiang, China.
Department of Psychosomatic Diseases, Hangzhou Seventh People's Hospital, Hangzhou, Zhejiang, China.
Front Nutr. 2024 Nov 1;11:1468284. doi: 10.3389/fnut.2024.1468284. eCollection 2024.
This study aims to investigate the relationship between serum vitamin D levels and the atherogenic index of plasma (AIP) in individuals aged 20 years and above, as well as analyze potential influencing factors.
A total of 9,637 participants aged 20 years and above from the National Health and Nutrition Examination Survey (NHANES) conducted between 2011 and 2018 were included in this study. The AIP was calculated using the formula log[triglycerides (TG)/high-density lipoprotein cholesterol (HDL-C)]. Due to the skewed distribution of serum vitamin D levels in the study population, a normal transformation was performed. Weighted multivariate linear regression models were used to assess the linear relationship between the transformed serum vitamin D levels and AIP. Subgroup analysis was conducted by stratifying the data based on age, gender, and race to evaluate the stability of the relationship between serum vitamin D levels and AIP in different populations. In addition, a smooth curve fitting and generalized linear models were employed to examine the nonlinear relationship between serum vitamin D levels and AIP.
After controlling for confounding factors, the multivariate linear regression analysis revealed a negative correlation between serum vitamin D levels and AIP [ = -0.0065, 95% CI: (-0.0106, -0.0024)]. This negative correlation was significant in male participants [ = -0.0077, 95% CI: (-0.0142, -0.0011)], Non-Hispanic Black participants [ = -0.0135, 95% CI: (-0.0211, -0.0059)], as well as participants aged 40-50 [ = -0.0124, 95% CI: (-0.0226, -0.0022)] and 60-70 [β = -0.0118, 95% CI: (-0.0214, -0.0023)]. Furthermore, a nonlinear relationship and saturation effect were observed between the transformed serum vitamin D levels and AIP, with a turning point at 8.5617 nmol/L.
Our study revealed a significant negative correlation and saturation effect between serum vitamin D levels and AIP.
本研究旨在调查20岁及以上人群血清维生素D水平与血浆致动脉粥样硬化指数（AIP）之间的关系，并分析潜在影响因素。
本研究纳入了2011年至2018年期间美国国家健康与营养检查调查（NHANES）中的9637名20岁及以上参与者。AIP采用公式log[甘油三酯（TG）/高密度脂蛋白胆固醇（HDL-C）]计算。由于研究人群中血清维生素D水平呈偏态分布，故进行了正态转换。采用加权多元线性回归模型评估转换后的血清维生素D水平与AIP之间的线性关系。通过按年龄、性别和种族对数据进行分层来进行亚组分析，以评估不同人群中血清维生素D水平与AIP之间关系的稳定性。此外，采用平滑曲线拟合和广义线性模型来检验血清维生素D水平与AIP之间的非线性关系。
在控制混杂因素后，多元线性回归分析显示血清维生素D水平与AIP呈负相关[β = -0.0065，95%CI：（-0.0106，-0.0024）]。这种负相关在男性参与者[β = -0.0077，95%CI：（-0.0142，-0.0011）]、非西班牙裔黑人参与者[β = -0.0135，95%CI：（-0.0211，-0.0059）]以及40 - 50岁[β = -0.0124，95%CI：（-0.0226，-0.0022）]和60 - 70岁[β = -0.0118，95%CI：（-0.0214，-0.0023）]的参与者中具有统计学意义。此外，在转换后的血清维生素D水平与AIP之间观察到非线性关系和饱和效应，转折点为8.5617 nmol/L。
我们的研究揭示了血清维生素D水平与AIP之间存在显著的负相关和饱和效应。
