Sun Rui, Tao Juan, Tang Na, Chen Zhijun, Guo Xiaowei, Zou Lianhong, Zhou Junhua
Key Laboratory of Molecular Epidemiology of Hunan Province, School of Medicine, Hunan Normal University, Changsha, 410013, Hunan, China.
Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University), Changsha, Hunan 410013, P.R. China.
Iran J Public Health. 2024 Jan;53(1):1-11. doi: 10.18502/ijph.v53i1.14678.
Influenza is the first infectious disease that implements global monitoring and is one of the major public health issues in the world. Air pollutants have become an important global public health issue, in recent years, and much epidemiological and clinical evidence has shown that air pollutants are associated with respiratory diseases.
We comprehensively searched articles published up to 15 November 2022 in PubMed, Web of Science, China National Knowledge Infrastructure (CNKI), Database of Chinese sci-tech periodicals, and Wanfang Database. The search strategies were based on keyword combinations related to influenza and air pollutants. The air pollutants included particulate matter (PM, PM), nitrogen dioxide (NO), sulfur dioxide (SO), carbon monoxide (CO), and ozone (O). Meta-analysis was performed using the R programming language (R4.2.1).
A total of 2926 records were identified and 1220 duplicates were excluded. Finally, 19 studies were included in the meta-analysis according to inclusion and exclusion criteria. We observed a significant association between partial air pollutants (PM, NO, PM and SO) and the incidence risk of influenza. The RRs were 1.0221 (95% CI: 1.00931.0352), 1.0395 (95% CI: 1.01311.0666), 1.007 (95% CI: 1.00091.0132), and 1.0352 (95% CI. 1.00761.0635), respectively. However, there was no significant relationship between CO and O exposure and influenza, and the RRs were 1.2272 (95% CI: 0.92531.6275) and 1.0045 (95% CI: 0.99301.0160), respectively.
Exposure to PM, NO, PM, and SO was significantly associated with influenza, which may be risk factors for influenza. The association of CO and O with influenza needs further investigation.
流感是首个实施全球监测的传染病，也是全球主要的公共卫生问题之一。近年来，空气污染物已成为一个重要的全球公共卫生问题，大量流行病学和临床证据表明，空气污染物与呼吸道疾病有关。
我们全面检索了截至2022年11月15日在PubMed、科学网、中国知网、中国科技期刊数据库和万方数据库上发表的文章。检索策略基于与流感和空气污染物相关的关键词组合。空气污染物包括颗粒物（PM、PM）、二氧化氮（NO）、二氧化硫（SO）、一氧化碳（CO）和臭氧（O）。使用R编程语言（R4.2.1）进行荟萃分析。
共识别出2926条记录，排除1220条重复记录。最后，根据纳入和排除标准，19项研究被纳入荟萃分析。我们观察到部分空气污染物（PM、NO、PM和SO）与流感发病风险之间存在显著关联。相对危险度分别为1.0221（95%可信区间：1.00931.0352）、1.0395（95%可信区间：1.01311.0666）、1.007（95%可信区间：1.00091.0132）和1.0352（95%可信区间：1.00761.0635）。然而，CO和O暴露与流感之间无显著关系，相对危险度分别为1.2272（95%可信区间：0.92531.6275）和1.0045（95%可信区间：0.99301.0160）。
暴露于PM、NO、PM和SO与流感显著相关，可能是流感的危险因素。CO和O与流感的关联需要进一步研究。
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