Health Outcomes Research Unit, University Hospital of Psychiatry II, Medical University of Innsbruck, Innrain 43, Innsbruck, 6020, Austria.
Psychological Diagnostics and Intervention, Catholic University of Eichstätt-Ingolstadt, Eichstätt, Germany.
J Patient Rep Outcomes. 2024 May 2;8(1):48. doi: 10.1186/s41687-024-00719-7.
General population normative values for the widely used health-related quality of life (HRQoL) measure EORTC QLQ-C30 support the interpretation of trial results and HRQoL of patients in clinical practice. Here, we provide sex-, age- and health condition-specific normative values for the EORTC QLQ-C30 in the French general population.
French general population data was collected in an international EORTC project. Online panels with quota samples were used to recruit sex and age groups. Number and type of comorbidities were assessed. Descriptive statistics were used to calculate general population values for each QLQ-C30 scale, separately for sex, age, and presence of one- and more chronic health conditions. A multivariate linear regression model has been developed to allow estimating the effect of sex, age, and the presence for one- and more chronic health conditions on EORTC QLQ-C30 scores. Data was weighted according to United Nation statistics adjusting for the proportion of sex and age groups.
In total, 1001 French respondents were included in our analyses. The weighted mean age was 47.9 years, 514 (51.3%) participants were women, and 497 (52.2%) participants reported at least one health condition. Men reported statistically significant better scores for Emotional Functioning (+9.6 points, p = 0.006) and Fatigue (-7.8 point; p = 0.04); women reported better profiles for Role Functioning (+8.7 points; p = 0.008) and Financial Difficulty (-7.8 points, p = 0.011). According to the regression model, the sex effect was statistically significant in eight scales; the effect of increasing age had a statistically significant effect on seven of the 15 EORTC QLQ-C30 scales. The sex- and age effect varied in its direction across the various scales. The presence of health conditions showed a strong negative effect on all scales.
This is the first publication of detailed French normative values for the EORTC QLQ-C30. It aims to support the interpretation of HRQoL profiles in French cancer populations. The strong impact of health conditions on QLQ-C30 scores highlights the importance of considering the impact of comorbidities in cancer patients when interpreting HRQoL data.
广泛使用的健康相关生活质量（HRQoL）量表 EORTC QLQ-C30 的一般人群参考值支持对临床试验结果和临床实践中患者的 HRQoL 的解释。在这里，我们提供了法国一般人群中 EORTC QLQ-C30 的性别、年龄和健康状况特定的参考值。
从一个国际 EORTC 项目中收集了法国一般人群的数据。使用具有配额样本的在线小组招募了不同性别和年龄组的参与者。评估了合并症的数量和类型。使用描述性统计数据分别计算了每个 QLQ-C30 量表的一般人群值，按性别、年龄以及存在一种或多种慢性健康状况进行了划分。开发了一个多元线性回归模型，以允许估计性别、年龄以及存在一种或多种慢性健康状况对 EORTC QLQ-C30 评分的影响。根据联合国统计数据，根据性别和年龄组的比例对数据进行了加权调整。
共有 1001 名法国受访者纳入了我们的分析。加权平均年龄为 47.9 岁，514 名（51.3%）参与者为女性，497 名（52.2%）参与者报告至少有一种健康状况。男性在情感功能（+9.6 分，p=0.006）和疲劳（-7.8 分，p=0.04）方面的报告得分明显更好；女性在角色功能（+8.7 分，p=0.008）和经济困难（-7.8 分，p=0.011）方面的报告得分更好。根据回归模型，性别效应在 8 个量表中具有统计学意义；年龄增加的效应在 15 个 EORTC QLQ-C30 量表中的 7 个量表中具有统计学意义。性别的年龄效应在不同的量表中方向不同。健康状况的存在对所有量表都有强烈的负面影响。
这是第一个关于 EORTC QLQ-C30 的详细法国参考值的出版物。它旨在支持对法国癌症人群 HRQoL 特征的解释。健康状况对 QLQ-C30 评分的强烈影响突出了在解释 HRQoL 数据时考虑合并症对癌症患者的影响的重要性。
