Oncology Departments, Complejo Hospitalario de Navarra, Irunlarrea 3, 31008, Pamplona, Spain.
Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Medical Clinic, Department of Psychosomatic Medicine, Berlin, Germany.
Health Qual Life Outcomes. 2021 Aug 30;19(1):208. doi: 10.1186/s12955-021-01820-x.
General population normative data for the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30 questionnaire facilitates interpretation of data assessed from cancer patients. This study aims to present normative data of the general Spanish population.
METHODS/PATIENTS: Data were obtained from a prior larger study collecting EORTC QLQ-C30 norm data across 15 countries. Data were stratified by sex and age groups (18-39, 40-49, 50-59, 60-69 and > 70 years). Sex and age distribution were weighted according to population distribution statistics. Sex- and age-specific normative values were analysed separately, as were participants with versus those without health conditions. Multiple linear regression was used to estimate the association of each of the EORTC QLQ-C30 scales with the determinants age, sex, sex-by-age interaction term, and health condition.
In total, 1,165 Spanish individuals participated in the study. Differences were found by sex and age. The largest sex-related differences were seen in fatigue, emotional functioning, and global QOL (Quality of Life), favouring men. The largest age differences were seen in emotional functioning, insomnia, and pain, with middle-aged groups having the worst scores. Those > 60 years old scored better than those < 60 years old on all scales except for physical functioning. Participants with no health conditions scored better in all QLQ-C30 domains.
The present study highlights differences in HRQOL between specific sex/age strata and especially between people with and without a health condition in the general Spanish population. These factors must be considered when comparing general population HRQOL data with that of cancer patients.
欧洲癌症研究与治疗组织（EORTC）QLQ-C30 问卷的一般人群规范数据有助于解释从癌症患者评估的数据。本研究旨在介绍一般西班牙人群的规范数据。
方法/患者：数据来自先前一项更大规模的研究，该研究在 15 个国家收集 EORTC QLQ-C30 规范数据。数据按性别和年龄组（18-39、40-49、50-59、60-69 和>70 岁）进行分层。根据人口分布统计数据对性别和年龄分布进行加权。分别分析了性别和年龄特异性规范值，以及有和没有健康状况的参与者。使用多元线性回归估计 EORTC QLQ-C30 各量表与年龄、性别、性别-年龄交互项和健康状况等决定因素的关联。
共有 1165 名西班牙人参与了这项研究。结果发现存在性别和年龄差异。在疲劳、情绪功能和总体生活质量（QOL）方面，男女之间的差异最大，男性表现更好。在情绪功能、失眠和疼痛方面，年龄差异最大，中年组得分最差。60 岁以上的人在所有量表上的得分都比 60 岁以下的人好，除了身体功能。没有健康状况的参与者在所有 QLQ-C30 领域的得分都更好。
本研究强调了特定性别/年龄组之间以及有和没有健康状况的一般西班牙人群之间 HRQOL 的差异。在将一般人群的 HRQOL 数据与癌症患者的数据进行比较时，必须考虑这些因素。
