The Xuzhou Clinical College of Xuzhou Medical University, Xuzhou, Jiangsu, China.
Department of Endocrinology, Xuzhou Central Hospital, Xuzhou Institute of Medical Sciences, Xuzhou Clinical School of Nanjing Medical University, Affiliated Hospital of Medical School of Southeast University, Jiangsu, China.
PLoS One. 2024 May 2;19(5):e0301484. doi: 10.1371/journal.pone.0301484. eCollection 2024.
The klotho protein, a multifunctional protein, has been shown to be associated with a wide range of endocrine diseases and has been linked to thyroid tumourigenesis. However, the relationship between serum klotho levels and thyroid hormones remains poorly understood. This study aimed to explore the correlation between serum klotho levels and thyroid hormones.
Data was obtained from the NHANES cycles 2007-2008, 2009-2010, and 2011-2012. A total of 4674 participants were recruited for this study. Statistical analysis was using multiple linear regression analyses, and restricted cubic spline plots (RCS) to investigate the association between serum klotho levels and serum levels of thyroid hormones.
In the unadjusted covariate model, ln(klotho) significantly positively correlated with tT3, tT4, fT3, tT4/fT4, and tT3/fT3 (all P<0.01) and negatively correlated with TSH, tT4/tT3, and fT4/fT3 (all P<0.05). Furthermore, tT3, tT4, fT3and tT3/fT3 (P < 0.05) were still significant in the adjusted model. And it is worth noting that there is an approximately L-shaped nonlinear relationship between ln(klotho) and fT3,tT3 with a cut-off point of 6.697 (P-non-linear < 0.05). The stratification analysis showed gender and iodine level differences in the relationship between serum Klotho levels and thyroid hormones.
There is an L-shaped nonlinear relationship between ln(klotho) and fT3, tT3, suggesting that klotho could be involved in the physiological regulation of thyroid function.
Klotho 蛋白是一种多功能蛋白，已被证明与多种内分泌疾病相关，并与甲状腺肿瘤的发生有关。然而，血清 Klotho 水平与甲状腺激素之间的关系仍知之甚少。本研究旨在探讨血清 Klotho 水平与甲状腺激素之间的相关性。
本研究的数据来自 NHANES 周期 2007-2008、2009-2010 和 2011-2012。共招募了 4674 名参与者。采用多元线性回归分析和限制立方样条图（RCS）对血清 Klotho 水平与甲状腺激素水平之间的关系进行统计分析。
在未调整的协变量模型中，ln（Klotho）与 tT3、tT4、fT3、tT4/fT4 和 tT3/fT3 呈显著正相关（均 P<0.01），与 TSH、tT4/tT3 和 fT4/fT3 呈显著负相关（均 P<0.05）。此外，在调整后的模型中，tT3、tT4、fT3 和 tT3/fT3 仍具有统计学意义（P<0.05）。值得注意的是，ln（Klotho）与 fT3、tT3 之间存在近似 L 形非线性关系，其截断点为 6.697（P-非线性<0.05）。分层分析显示，血清 Klotho 水平与甲状腺激素之间的关系存在性别和碘水平差异。
ln（Klotho）与 fT3、tT3 之间呈 L 形非线性关系，提示 Klotho 可能参与甲状腺功能的生理调节。
