Department of Endocrinology, General Hospital of Central Theater Command, Wuluo Road 627, Wuhan, 430070, Hubei Province, China.
BMC Endocr Disord. 2024 Aug 28;24(1):161. doi: 10.1186/s12902-024-01687-1.
Thyroid hormone is the key endocrine regulator of growth, development, metabolism, and other bodily functions. α-Klotho has been involved in the aging process and acts as an endocrine factor involved in the regulation of various metabolic processes in humans. However, the relationship between α-Klotho and thyroid profile has not been uniformly recognize.
To determine the relationship between α-Klotho and thyroid profile in adult individuals.
Population data of 4614 adult individuals were obtained from the NHANES database during the period of 2007-2012. Weighted multivariable regression analysis was performed using a general linear model with serum α-Klotho as the independent variable and thyroid profile as the dependent variables, respectively. The generalized additive model was used for smoothing curve fitting and threshold effect analysis.
α-Klotho was associated with a slightly higher FT3, TT3 and TT4 level in unadjusted and adjusted regression models. However, a higher α-Klotho level was associated with a lower TSH level. After α-Klotho was grouped as quantiles with reference (Q1), α-Klotho still showed a statistically significant positive correlation with FT3 and TT3 levels in Q2, Q3 and Q4. In addition, α-Klotho was positively corrected with TT4, but negatively associated with TSH in Q4.
Serum soluble α-Klotho was positively associated with FT3, TT3 and TT4, but negatively correlated with TSH. The significant effect of α-Klotho on thyroid profile suggests its potential as a predictive marker of thyroid functions, indicating its possible involvement in the regulation of thyroid hormone secretion.
甲状腺激素是生长、发育、代谢和其他身体功能的关键内分泌调节剂。α-klotho 参与衰老过程，并作为一种内分泌因子，参与调节人类的各种代谢过程。然而，α-klotho 与甲状腺谱之间的关系尚未得到统一认可。
确定成年个体中 α-klotho 与甲状腺谱之间的关系。
从 2007-2012 年 NHANES 数据库中获取了 4614 名成年个体的人群数据。使用一般线性模型，以血清 α-klotho 为自变量，甲状腺谱为因变量，分别进行加权多变量回归分析。使用广义加性模型进行平滑曲线拟合和阈值效应分析。
在未调整和调整后的回归模型中，α-klotho 与 FT3、TT3 和 TT4 水平略高相关。然而，较高的 α-klotho 水平与较低的 TSH 水平相关。将 α-klotho 分为 Q1 参考组后，α-klotho 在 Q2、Q3 和 Q4 中仍与 FT3 和 TT3 水平呈统计学显著正相关。此外，α-klotho 与 TT4 呈正相关，与 Q4 中的 TSH 呈负相关。
血清可溶性 α-klotho 与 FT3、TT3 和 TT4 呈正相关，与 TSH 呈负相关。α-klotho 对甲状腺谱的显著影响表明其可能作为甲状腺功能的预测标志物，提示其可能参与甲状腺激素分泌的调节。
