Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy Department, Ocean University of China, Qingdao, Shandong, 266003, China; Laboratory of Marine Drugs and Biological Products, National Laboratory for Marine Science and Technology, Qingdao, Shandong 266235, China.
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy Department, Ocean University of China, Qingdao, Shandong, 266003, China; Laboratory of Marine Drugs and Biological Products, National Laboratory for Marine Science and Technology, Qingdao, Shandong 266235, China; State Key Laboratory of Marine Food Processing & Safety Control, College of Food Science and Engineering, Ocean University of China, Qingdao, 266003, China.
Phytochemistry. 2024 Jul;223:114113. doi: 10.1016/j.phytochem.2024.114113. Epub 2024 May 1.
Eleven undescribed cembrane-type diterpenoids, named litoamentenes A-K (1-11), were isolated from the soft coral Litophyton amentaceum collected from the South China Sea. Their structures were elucidated by extensive analysis of spectroscopic data, comparison with the literature data, single crystal X-ray diffraction, quantum chemical calculations and TDDFT-ECD calculations. This is the first systematic investigation of L. amentaceum. In particular, compounds 1-3 are cembrane-type norditerpenoids that lack isopropyl side chains. Compound 6 is a cembrane-type norditerpenoid without a methyl group at C-4, the first natural product identified with this carbon skeleton. Compounds 6, 9 and 10 showed modest cytotoxicity against several human cancer cell lines with IC values ranging from 3.99 to 14.56 μM.
从南海采集的软珊瑚 Litophyton amentaceum 中分离得到了 11 种未被描述的海松烷型二萜类化合物，命名为 litoamentenes A-K（1-11）。通过广泛的光谱数据分析、与文献数据的比较、单晶 X 射线衍射、量子化学计算和 TDDFT-ECD 计算，确定了它们的结构。这是对 L.amentaceum 的首次系统研究。特别是，化合物 1-3 是缺乏异丙基侧链的海松烷型降二萜类化合物。化合物 6 是一种 C-4 位没有甲基的海松烷型降二萜类化合物，是第一个被鉴定具有这种碳骨架的天然产物。化合物 6、9 和 10 对几种人癌细胞系表现出适度的细胞毒性，IC 值范围为 3.99-14.56 μM。
